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Journals / Experimed / 2023 / Volume: 13 Issue: 3

Effect of MCP-1 and CCR2 Serum Levels on COVID-19 Severity

Selen Zeliha Mart Kömürcü(Kanuni Sultan Suleyman Training and Research Hospital, Department of Microbiology)0000-0001-7500-0783
Şeydanur Doğan(Nisantası University, School of Health Services, Medical Laboratory Techniques Program)0000-0001-5245-5275
Ebru Kaya(Kanuni Sultan Suleyman Training and Research Hospital, Department of Anesthesia and Reanimation)0000-0002-9506-0756
Sevim Yavaş(Kanuni Sultan Suleyman Training and Research Hospital, Department of Infectious Diseases)0000-0001-8010-7454
Serkan Doğan(Kanuni Sultan Suleyman Training and Research Hospital, Department of Emergency Medicine)0000-0001-8923-2489
Utku Murat Kalafat(Kanuni Sultan Suleyman Training and Research Hospital, Department of Emergency Medicine)0000-0003-1749-8098
Hayriye Şentürk Çiftçi(Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology)0000-0003-3507-482X
Selçuk Daşdemir(Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology)0000-0002-7816-8909
Journal
Experimed
Pages
—
Publication Date
2023-12-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, by measuring serum levels of MCP-1 and CCR2 early, the disease course can be predicted , and necessary precautions can be taken before the disease becomes severe.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Approximately 80% of people with coronavirus disease 2019 (COVID-19) are asymptomatic, and only a small proportion of cases show serious consequences leading to hospitalization.
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Key Findings & Data:The interplay of monocyte chemoattractant protein-1 (MCP-1) with its receptor C-C motif chemokine receptor 2 (CCR2) may affect the pathogenesis of COVID-19 by functioning in the dispatch of lymphocytes and monocytes/macrophages to the infection site.
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Conclusion & Impact:Therefore, by measuring serum levels of MCP-1 and CCR2 early, the disease course can be predicted , and necessary precautions can be taken before the disease becomes severe.
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:MCP-1 · CCR2 · COVID-19 severity

Abstract

Objective: Approximately 80% of people with coronavirus disease 2019 (COVID-19) are asymptomatic, and only a small proportion of cases show serious consequences leading to hospitalization. The interplay between chemokines and their receptors can affect the severity of several infectious diseases, such as severe acute respiratory syndrome and Middle East Respiratory Syndrome. The interplay of monocyte chemoattractant protein-1 (MCP-1) with its receptor C-C motif chemokine receptor 2 (CCR2) may affect the pathogenesis of COVID-19 by functioning in the dispatch of lymphocytes and monocytes/macrophages to the infection site. Materials and Methods: The serum MCP-1 and CCR2 concentrations were measured using the enzyme-linked immunosorbent assay (ELISA) in 49 asymptomatic, 50 severe, and 57 critical COVID-19 cases. Results: Serum MCP-1 levels were considerably higher in critical cases than in cases in the other two groups, suggesting an increased risk for disease severity (p = 0.008; p = 0.01, respectively). Serum CCR2 levels were significantly higher in asymptomatic cases than in critical cases suggesting a protective role against disease severity (p = 0.001). Conclusion: MCP-1 and CCR2 may be candidate biomarkers for the prediction of disease severity. Therefore, by measuring serum levels of MCP-1 and CCR2 early, the disease course can be predicted , and necessary precautions can be taken before the disease becomes severe.

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Cite This Article

Kömürcü, S. Z. M., Doğan, Ş., Kaya, E., Yavaş, S., Doğan, S., Kalafat, U. M., Çiftçi, H. Ş., Daşdemir, S. (2023). Effect of MCP-1 and CCR2 Serum Levels on COVID-19 Severity. Experimed, Volume: 13 Issue: 3. https://doi.org/10.26650/experimed.1381077

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