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Journals / Experimed / 2026 / Volume: 14 Issue: 2

Relationship Between BDNF and LPS Levels in the Blood of Patients with Different Neurological Diseases: A Small Cohort Study

Nur Damla Korkmaz(ISTANBUL UNIVERSITY, AZIZ SANCAR INSTITUTE OF EXPERIMENTAL MEDICINE, DEPARTMENT OF NEUROSCIENCE)0000-0002-1173-1701
Birsen Elibol(ISTANBUL MEDENIYET UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, MEDICAL DEPARTMENT OF BIOLOGY)0000-0002-9462-0862
Seda Süsgün(Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology)0000-0001-9689-3111
Ceyhun Toruntay(ISTANBUL TECHNICAL UNIVERSITY, FACULTY OF ARTS AND SCIENCES, DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS, DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS)0000-0002-4743-0257
Alişan Bayrakoğlu(BEZMI ALEM FOUNDATION UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF NEUROLOGY)0000-0001-9620-2237
Mazlum Yuzgulec(BEZMI ALEM FOUNDATION UNIVERSITY, SCHOOL OF MEDICINE)0009-0006-8949-0529
Zihni Elagoz(BEZMI ALEM FOUNDATION UNIVERSITY, SCHOOL OF MEDICINE)0009-0006-0517-8133
Ayşegül Yabacı Tak(BEZMI ALEM FOUNDATION UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOSTATISTICS AND INFORMATICS MEDICINE)0000-0002-5813-3397
Emrah Yücesan(University-Cerrahpasa, Institute of Neurological Sciences, Department of Neurogenetics)0000-0003-4512-8764
Ferda İlgen Uslu(BEZMI ALEM FOUNDATION UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF NEUROLOGY)0000-0002-2124-5037
Gülsen Babacan Yıldız(BEZMI ALEM FOUNDATION UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF NEUROLOGY)0000-0003-0922-0969
Azize Esra Başar Gürsoy(Basaksehir Cam and Sakura City Hospital, Department of Neurology)0000-0002-8103-0927
Fahri Akbaş(Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology)0000-0002-3837-250X
Bilge Sümbül(BEZMI ALEM FOUNDATION UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF MEDICAL MICROBIOLOGY)0000-0002-8768-3777
Journal
Experimed
Pages
—
Publication Date
2024-08-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Neuroinflammation and blood-brain barrier (BBB) dysfunction are key factors in various neurological disorders, disrupting brain tissue balance and leading to neuronal death.
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Key Findings & Data:Results: Significant associations were observed between LPS, C-reactive protein (CRP), BDNF, and lactate dehydrogenase (LDH) levels across conditions.
💡
Conclusion & Impact:Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Brain-derived neurotrophic factor · lipopolysaccharide · neuroinflammation

Abstract

Objective: Neuroinflammation and blood-brain barrier (BBB) dysfunction are key factors in various neurological disorders, disrupting brain tissue balance and leading to neuronal death. BBB integrity decline is evident in Alzheimer's Disease (AD), Parkinson's Disease (PD), Multiple Sclerosis (MS), and epilepsy. Materials and Methods: We measured levels of lipopolysaccharide (LPS), the largest endotoxin, and brain-derived neurotrophic factor (BDNF) in patients' blood plasma and correlated them with biochemical parameters to identify biomarkers for these diseases. Results: Significant associations were observed between LPS, C-reactive protein (CRP), BDNF, and lactate dehydrogenase (LDH) levels across conditions. LPS was positively correlated with CRP levels in epilepsy (r=0.753, p=0.002). Additionally, BDNF was negatively correlated with CRP in PD patients (r=-0.53, p=0.042). Moreover, a negative correlation was found between LPS and LDH in AD patients (r=-0.521, p=0.047). Conclusion: Our findings correspond to the etiology of neuroinflammation involved in the pathophysiology of relevant diseases and suggest the potential use of these biomarkers in the early diagnosis and monitoring of neurological diseases, guiding future research towards better patient outcomes and therapies.

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Cite This Article

Korkmaz, N. D., Elibol, B., Süsgün, S., Toruntay, C., Bayrakoğlu, A., Yuzgulec, M., Elagoz, Z., Tak, A. Y., Yücesan, E., Uslu, F. İ., Yıldız, G. B., Gürsoy, A. E. B., Akbaş, F., Sümbül, B. (2024). Relationship Between BDNF and LPS Levels in the Blood of Patients with Different Neurological Diseases: A Small Cohort Study. Experimed, Volume: 14 Issue: 2. https://doi.org/10.26650/experimed.1472096

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