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Journals / Experimed / 2025 / Volume: 15 Issue: 3

Differential Myokine Responses to Swimming: Highlighting Meteorin-like (Metrnl) as a Unique Marker of Adaptation

Alten Oskay(PAMUKKALE ÜNİVERSİTESİ)0000-0003-4373-6280
Özgen Kılıç Erkek(PAMUKKALE UNIVERSITY)0000-0001-8037-099X
Hande Şenol(PAMUKKALE UNIVERSITY)0000-0001-6395-7924
Mert Özen(PAMUKKALE UNIVERSITY)0000-0001-6653-3756
Egem Burcu Ünal(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-9499-2316
Z. Melek Küçükatay(PAMUKKALE UNIVERSITY)0000-0002-9366-0205
Journal
Experimed
Pages
—
Publication Date
2025-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: These findings suggest that unlike FSTL1, IL-7, and IL-8, only Metrnl may play a role in mediating adaptation to long-term exercise in mice.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We examined time-dependent changes in levels of Metrnl, IL-7, IL-8, and FSTL1 myokines in mouse gastrocnemius-soleus tissue and plasma samples in response to acute and long-term swimming exercises.
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Key Findings & Data:Material and Method: Seventy 8–12-week-old adult male BALB/c mice were divided into control and exercise groups.
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Conclusion & Impact:Conclusion: These findings suggest that unlike FSTL1, IL-7, and IL-8, only Metrnl may play a role in mediating adaptation to long-term exercise in mice.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Follistatin-like 1 protein · interleukin-7 · interleukin-8

Abstract

Objective: We examined time-dependent changes in levels of Metrnl, IL-7, IL-8, and FSTL1 myokines in mouse gastrocnemius-soleus tissue and plasma samples in response to acute and long-term swimming exercises. Material and Method: Seventy 8–12-week-old adult male BALB/c mice were divided into control and exercise groups. The exercise group was subjected to either an acute or chronic exercise regime and examined at 0, 3, and 48 h. The acute exercise group completed a 30-min single swimming session. The chronic exercise group completed the 30-min swimming exercise every day, 5 days a week, for 6 weeks. Metrnl, IL-7, IL-8, and FSTL1 levels in the gastrocnemius-soleus muscle complex and plasma samples were measured using ELISA kits. Results: No changes were observed in the Metrnl, IL-7, IL-8, and FSTL1 levels in the gastrocnemius-soleus muscle complex following acute or 6 weeks of swimming exercise. IL-7, IL-8, and FSTL1 levels did not change in the plasma in response to the exercises. However, plasma Metrnl levels were higher at 3 h after 6 weeks of exercise compared to the control group or the 3-h sample of the acute exercise group. Conclusion: These findings suggest that unlike FSTL1, IL-7, and IL-8, only Metrnl may play a role in mediating adaptation to long-term exercise in mice.

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Cite This Article

Oskay, A., Erkek, Ö. K., Şenol, H., Özen, M., Ünal, E. B., Küçükatay, Z. M. (2025). Differential Myokine Responses to Swimming: Highlighting Meteorin-like (Metrnl) as a Unique Marker of Adaptation. Experimed, Volume: 15 Issue: 3. https://doi.org/10.26650/experimed.1690894

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