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Journals / İstanbul Tıp Fakültesi Dergisi / 2026 / Cilt: 85 Sayı: 3

TACROLIMUS ASSOCIATED HEMORRHAGIC POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME: A RARE CASE IN THE LATE PERIOD AFTER RENAL TRANSPLANTATION

TAKROLİMUS İLİŞKİLİ HEMORAJİK POSTERİOR REVERSİBL ENSEFALOPATİ SENDROMU: BÖBREK TRANSPLANTASYONU SONRASI GEÇ DÖNEMDE PREZENTE OLAN NADİR BİR OLGU

Yasemin Akıncı(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, NÖROLOJİ ANABİLİM DALI)0000-0001-6984-033X
Nurhan Seyahi(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI, NEFROLOJİ BİLİM DALI)0000-0001-7427-618X
Sabahattin Saip(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, NÖROLOJİ ANABİLİM DALI)0000-0002-2802-7227
Aysegul Gunduz(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, NÖROLOJİ ANABİLİM DALI)0000-0003-2365-0850
Pages
440–444
Publication Date
2022-07-06
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this case report, to draw attention to this dramatic side effect of calcineurin inhibitors, we present a case of hemorrhagic PRES, which developed in the late period after kidney transplantation most likely associated with tacrolimus treatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Immunosuppressive agents such as calcineurin inhibitors, which are commonly used in transplant patients may play a role in the development of posterior reversible encephalopathy syndrome (PRES), one of the rare neurological complications after organ and tissue transplantation.
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Key Findings & Data:This complication, which is often seen in the early period after transplantation, occurs in the late period in a small number of cases.
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Conclusion & Impact:In this case report, to draw attention to this dramatic side effect of calcineurin inhibitors, we present a case of hemorrhagic PRES, which developed in the late period after kidney transplantation most likely associated with tacrolimus treatment.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:PRES · tacrolimus · kalsinörin inhibitörleri

Abstract

Immunosuppressive agents such as calcineurin inhibitors, which are commonly used in transplant patients may play a role in the development of posterior reversible encephalopathy syndrome (PRES), one of the rare neurological complications after organ and tissue transplantation. This complication, which is often seen in the early period after transplantation, occurs in the late period in a small number of cases. In this case report, to draw attention to this dramatic side effect of calcineurin inhibitors, we present a case of hemorrhagic PRES, which developed in the late period after kidney transplantation most likely associated with tacrolimus treatment.

Özet

Organ ve doku transplantasyonu sonrası nadir görülen nörolojik komplikasyonlardan birisi olan posterior reversible ensefalopati sendromunun (PRES) gelişiminde, transplantasyon hastalarında sıkça kullanılan kalsinörin inhibitörleri gibi immünsüpresif ajanlar rol oynayabilmektedir. Sıklıkla transplantasyon sonrası erken dö- nemde görülen bu komplikasyon az sayıda olguda geç dönem- de meydana gelebilmektedir. Bu olgu sunumunda, kalsinörin inhibitörlerinin bu şiddetli ve dramatik yan etkisine dikkat çek- mek için, böbrek nakli sonrası geç dönemde gelişen, kuvvetle muhtemel takrolimus tedavisi ile ilişkili hemorajik PRES olgusunu sunmaktayız.

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Cite This Article

Akıncı, Y., Seyahi, N., Saip, S., Gunduz, A. (2022). TACROLIMUS ASSOCIATED HEMORRHAGIC POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME: A RARE CASE IN THE LATE PERIOD AFTER RENAL TRANSPLANTATION. İstanbul Tıp Fakültesi Dergisi, Cilt: 85 Sayı: 3, 440–444. https://doi.org/10.26650/IUITFD.1040208

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