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Journals / İstanbul Tıp Fakültesi Dergisi / 2026 / Cilt: 89 Sayı: 1

PRIMARY GASTROINTESTINAL SYSTEM LYMPHOMA: ANALYSIS OF EIGHT PATIENTS IN A SINGLE-CENTER COHORT

PRİMER GASTROİNTESTİNAL SİSTEM LENFOMASI: TEK MERKEZLİ BİR KOHORTTA SEKİZ HASTANIN ANALİZİ

Zülal İstemihan(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI, GENEL DAHİLİYE BİLİM DALI)0000-0003-2961-2660
Mehmet Akif Yağlı(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0001-7613-0838
Pelin Telli(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0001-6927-717X
Gizem Dağcı(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0003-3554-4879
Sezen Genç Uluçeçen(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0001-7552-3816
Bilger Çavuş(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0003-2203-4255
Aslı Çifcibaşı Örmeci(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0001-6297-8045
Kadir Demir(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0002-5226-3705
Selman Fatih Beşışık(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0001-5184-376X
Sabahattin Kaymakoğlu(İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology)0000-0003-4910-249X
Pages
23–30
Publication Date
2026-02-09
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Primary gastrointestinal system lymphomas are rare diseases that can present in a wide age range and very different clinical presentations, and the small intestine was the most common involvement site in our cohort.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to investigate the features of eight patients diagnosed with primary gastrointestinal system lymphoma.
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Key Findings & Data:Materials and Methods: The features of patients diagnosed with primary gastrointestinal system lymphoma between 2021 and 2024 at the İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology, were retrospectively investigated.
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Conclusion & Impact:Conclusion: Primary gastrointestinal system lymphomas are rare diseases that can present in a wide age range and very different clinical presentations, and the small intestine was the most common involvement site in our cohort.
🔬Design:Araştırma Makalesi
📍Scope:2021 Verileri
⚙️Variables:Gastrointestinal sistem · Lenfoma · Karın ağrısı

Abstract

Objective: This study aimed to investigate the features of eight patients diagnosed with primary gastrointestinal system lymphoma. Materials and Methods: The features of patients diagnosed with primary gastrointestinal system lymphoma between 2021 and 2024 at the İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterohepatology, were retrospectively investigated. Results: Of the eight patients, 5 (62.5%) were male. The mean age was 55.1±18.8 (28–70) years. 4 (50%) patients had diabetes mellitus, one had Crohn's disease, one had decompensated cirrhosis, and one had compensated cirrhosis. The most common complaint of patients was stomachache. One of the patients who presented with stomachache had volvulus, one had ascites infection, and one had acute pancreatitis. Intestinal T-cell lymphoma was diagnosed in two, Burkitt lymphoma (BL) in two, Hodgkin lymphoma in one, mantle cell lymphoma (MCL) in one, follicular lymphoma in one and B-cell non-Hodgkin's lymphoma in one patients. The diagnosis of 4 (50%) patients was made by surgical resection, 3 (37.5%) patients were diagnosed by endoscopic biopsy and 1 (12.5%) patient was computerized by ascites fluid cytological examination and endoscopic biopsy. Four patients had lymphoma involvement in the small intestine, one patient had stomach, one patient had stomach and small intestine, one patient had spleen, and one patient had stomach, small intestine, and pancreas involvement. Conclusion: Primary gastrointestinal system lymphomas are rare diseases that can present in a wide age range and very different clinical presentations, and the small intestine was the most common involvement site in our cohort.

Özet

Amaç: Bu çalışmada primer gastrointestinal sistem lenfoması tanısı almış sekiz hastanın özellikleri araştırıldı. Gereç ve Yöntemler: İstanbul Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gastroenterohepatoloji Bilim Dalı'nda 2021-2024 yılları arasında primer gastrointestinal sistem lenfoması tanısı almış hastaların özellikleri retrospektif olarak incelendi. Bulgular: Çalışmada incelenen 8 hastanın 5'i (%62.5) erkekti. Hastaların yaş ortalaması 55.1±18.8 (28-70) yıldı. 4 (%50) hastada diabetes mellitus, bir hastada Crohn hastalığı, bir hastada dekompanse siroz, bir hastada kompanse siroz vardı. Hastaların en sık başvuru şikayeti karın ağrısıydı. Karın ağrısı ile başvuran hastalardan birinde volvulus, birinde asit enfeksiyonu, birinde ise akut pankreatit vardı. İki hastaya intestinal T hücreli lenfoma, iki hastaya Burkitt lenfoma, bir hastaya Hodgkin lenfoma, bir hastaya mantle hücreli lenfoma, bir hastaya foliküler lenfoma ve bir hastaya B hücreli non-Hodgkin lenfoma tanısı konuldu. 4 (%50) hastanın tanısı cerrahi rezeksiyonla, 3 (%37.5) hastanın tanısı endoskopik biyopsi ile, 1 (%12.5) hastanın tanısı ise assit sıvı sitolojisi incelemesi ve endoskopik biyopsi ile konuldu. Dört hastada ince barsak, bir hastada mide, bir hastada mide ve ince barsak, bir hastada dalak ve bir hastada mide, ince barsak ve pankreas tutulumu vardı. Sonuç: Primer gastrointestinal sistem lenfomaları geniş bir yaş aralığında ve çok farklı klinik prezentasyonlarla ortaya çıkabilennadir hastalıklardır ve kohortumuzda en sık tutulum bölgesi ince barsaktır

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Cite This Article

İstemihan, Z., Yağlı, M. A., Telli, P., Dağcı, G., Uluçeçen, S. G., Çavuş, B., Örmeci, A. Ç., Demir, K., Beşışık, S. F., Kaymakoğlu, S. (2026). PRIMARY GASTROINTESTINAL SYSTEM LYMPHOMA: ANALYSIS OF EIGHT PATIENTS IN A SINGLE-CENTER COHORT. İstanbul Tıp Fakültesi Dergisi, Cilt: 89 Sayı: 1, 23–30. https://doi.org/10.26650/IUITFD.11659103

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