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Journals / İstanbul Tıp Fakültesi Dergisi / 2026 / Cilt: 89 Sayı: 3

Prognostic Value of the HALP Score in Metastatic Urothelial Carcinoma Treated With First-Line Platinum-Based Chemotherapy

Fatih Atalah(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-5664-7853
Akgün Karakök(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0001-9876-3932
Aydın Acarbay(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-9446-9293
İsmail Nazlı(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-7495-3996
Onur Alkan(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8558-1654
Okan Aydın(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL PROF. DR. CEMİL TAŞÇIOĞLU ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0002-9516-992X
Mehmet Beşiroğlu(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1171-8320
Mahmut Gümüş(İSTANBUL MEDENİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-3550-9993
Pages
163–168
Publication Date
2026-08-14
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall survival (OS) was the primary endpoint, and progression-free survival (PFS) was the secondary end point.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Metastatic urothelial carcinoma (mUC) demonstrates substantial clinical heterogeneity, and outcomes may vary despite similar treatment approaches.
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Key Findings & Data:Materials and Methods: We retrospectively evaluated patients with metastatic or unresectable urothelial carcinoma who received first-line platinum-based chemotherapy at a single center between january 2015 and december 2023.
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Conclusion & Impact:Overall survival (OS) was the primary endpoint, and progression-free survival (PFS) was the secondary end point.
🔬Design:Araştırma Makalesi
📍Scope:2015 Verileri
⚙️Variables:metatatic urothelial carcinoma · inflammation · HALP score

Abstract

Objective: Metastatic urothelial carcinoma (mUC) demonstrates substantial clinical heterogeneity, and outcomes may vary despite similar treatment approaches. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has emerged as a potential prognostic biomarker reflecting nutritional, inflammatory, and immune status. This study evaluated the prognostic significance of HALP in patients with mUC treated with first-line platinum-based chemotherapy. Materials and Methods: We retrospectively evaluated patients with metastatic or unresectable urothelial carcinoma who received first-line platinum-based chemotherapy at a single center between january 2015 and december 2023. HALP scores were calculated using baseline laboratory parameters obtained before treatment initiation. Patients were stratified according to the median HALP value. Overall survival (OS) was the primary endpoint, and progression-free survival (PFS) was the secondary end point. Survival analyses were performed using the Kaplan – Meier and Cox regression methods. Results: A total of 118 patients were included. The median HALP value was 24; 64 patients were classified as low HALP and 54 as high HALP. Patients with low HALP had significantly poorer outcomes. Median PFS was 4.90 months in the low HALP group and 7.67 months in the high HALP group. Median OS was 5.82 and 20.33 months, respectively (p<0.001). In multivariable analysis, low HALP and age ≥ 65 years remained independently associated with worse OS. Conclusion: Low HALP score was associated with worse survival outcomes in patients with mUC receiving first-line platinum-based chemotherapy. As an easily obtainable laboratory-based index, HALP may provide additional prognostic information beyond conventional clinical factors.

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Cite This Article

Atalah, F., Karakök, A., Acarbay, A., Nazlı, İ., Alkan, O., Aydın, O., Beşiroğlu, M., Gümüş, M. (2026). Prognostic Value of the HALP Score in Metastatic Urothelial Carcinoma Treated With First-Line Platinum-Based Chemotherapy. İstanbul Tıp Fakültesi Dergisi, Cilt: 89 Sayı: 3, 163–168. https://doi.org/10.26650/IUITFD.1913645

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