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Journals / İstanbul Tıp Fakültesi Dergisi / 2026 / Cilt: 89 Sayı: 3

Percutaneous Cryoablation of T1A Renal Cell Carcinoma: Functional Outcomes and Residual Disease Management

Mehmet Semih Çakır(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE, İSTANBUL MEDICINE PR.)0000-0002-7072-5985
İlker Teke(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0009-0002-2294-4267
Celal Caner Ercan(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0003-2922-5847
Selçuk Erdem(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0002-3514-1394
Mehmet Öner Şanlı(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0001-5801-6898
Faruk Özcan(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0001-7544-6638
Bulent Acunas0000-0003-4695-6043
Pages
154–162
Publication Date
2026-08-14
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Percutaneous cryoablation achieved local tumor control with preservation of renal function and a low complication rate during follow-up in patients with T1a RCC.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This retrospective cohort study evaluated the efficacy, safety, and functional outcomes of percutaneous cryoablation in T1a renal cell carcinoma (RCC), with an emphasis on residual disease management and radiological follow-up.
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Key Findings & Data:Materials and Methods: Thirteen patients with 15 T1a RCC lesions treated with percutaneous cryoablation between September 2023 and June 2024 were retrospectively analyzed.
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Conclusion & Impact:Conclusion: Percutaneous cryoablation achieved local tumor control with preservation of renal function and a low complication rate during follow-up in patients with T1a RCC.
🔬Design:Araştırma Makalesi
📍Scope:2023 Verileri
⚙️Variables:Magnetic resonans imaging · percutaneous cryoablation · renal cell carcinoma

Abstract

Objective: This retrospective cohort study evaluated the efficacy, safety, and functional outcomes of percutaneous cryoablation in T1a renal cell carcinoma (RCC), with an emphasis on residual disease management and radiological follow-up. Materials and Methods: Thirteen patients with 15 T1a RCC lesions treated with percutaneous cryoablation between September 2023 and June 2024 were retrospectively analyzed. Clinical and follow-up data were collected. All procedures were performed under CT and US guidance using a standardized double freeze–thaw protocol. Follow-up included renal function assessment and radiological imaging with MRI or CT at the 3 rd month, 6 th month, and 1 year. Results: The study included 11 males (84.6%) and 2 females, with a median age of 62 years (range, 50-71 years). The median tumor diameter was 22 mm, and the PADUA score was 8. The median number of cryoablation probes used per procedure was 2 (range, 1-3), and the median procedural time was 60 minutes. Complete ablation was achieved in most patients; however, residual disease was detected in three patients during follow-up. Among those with residual disease, one underwent repeat cryoablation, one underwent surgery, and one underwent active surveillance. Complications were minor, including a single hematoma and one intracystic hemorrhage, both of which were asymptomatic. Renal function was preserved throughout the follow-up period, including in solitary kidney patients, with no clinically significant eGFR decline. Conclusion: Percutaneous cryoablation achieved local tumor control with preservation of renal function and a low complication rate during follow-up in patients with T1a RCC.

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Cite This Article

Çakır, M. S., Teke, İ., Ercan, C. C., Erdem, S., Şanlı, M. Ö., Özcan, F., Acunas, B. (2026). Percutaneous Cryoablation of T1A Renal Cell Carcinoma: Functional Outcomes and Residual Disease Management. İstanbul Tıp Fakültesi Dergisi, Cilt: 89 Sayı: 3, 154–162. https://doi.org/10.26650/IUITFD.1863207

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