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Journals / Journal of International Environmental Application and Science / 2026 / Volume: 14 Issue: 1

Determination of genotoxic effects in vitro of ZnOTiO2 nanoparticles on human peripheral lymphocytes

Yeşim Dağlıoğlu(ORDU ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ)0000-0001-8740-1162
Huri Özkan Yılmaz(GİRESUN ÜNİVERSİTESİ TIP FAKÜLTESİ)0000-0003-0257-7105
Orhan Yılmaz(GİRESUN ÜNİVERSİTESİ TIP FAKÜLTESİ)
Pages
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Publication Date
2019-03-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Again, there is no significant difference in the occurrence of MN depending on gender (P > 0.05).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study was to examine the genotoxic effects of ZnOTiO 2 NPs using chromosome aberration (CA) and micronucleus (MN) tests in human peripheral lymphocytes.
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Key Findings & Data:Cells were treated to ZnOTiO 2 NPs concentrations in the range of 12.5 to 125 µg/mL for 24 and 48 hours.
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Conclusion & Impact:Again, there is no significant difference in the occurrence of MN depending on gender (P > 0.05).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Chromosome aberration · ZnOTiO2 NPs · nanoparticles

Abstract

The aim of this study was to examine the genotoxic effects of ZnOTiO 2 NPs using chromosome aberration (CA) and micronucleus (MN) tests in human peripheral lymphocytes. Cells were treated to ZnOTiO 2 NPs concentrations in the range of 12.5 to 125 µg/mL for 24 and 48 hours. In addition, it induced structural CA at all concentrations with ZnOTiO 2 NPs treatment. However, nanoparticles did not stimulate CA in a dose-dependent manner for 24 and 48 hours of treatment, and there were no statistically significant differences between both the administration time and the concentrations (P > 0.05). The formation of MN induced by ZnOTiO 2 NPs increased depending on concentration and dose. In particular, the highest 2 concentrations (100 and 125 µg/ml ) were observed to be significantly increased during the 24 and 48 hour treatment period (P > 0.05). Again, there is no significant difference in the occurrence of MN depending on gender (P > 0.05).

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Cite This Article

Dağlıoğlu, Y., Yılmaz, H. Ö., Yılmaz, O. (2019). Determination of genotoxic effects in vitro of ZnOTiO2 nanoparticles on human peripheral lymphocytes. Journal of International Environmental Application and Science, Volume: 14 Issue: 1. https://ajindex.com/articles/1112346

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