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Journals / Trakya University Journal of Natural Sciences / 2026 / Volume: 26 Issue: 1

Melatonin - leptin interaction and obesity-related genes

Bülent Gündüz(CANAKKALE ONSEKIZ MART UNIVERSITY)0000-0003-0497-8287
Emine İnci Balkan(Demiroğlu Bilim University)0000-0002-2708-2427
Pages
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Publication Date
2025-04-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, the mo-lecular and hormonal mechanisms behind obesity were discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Most living organisms have circadian clocks which maintain rhythm in internal cycles of behavior, physiology, and metabolism, allowing them to anticipate the earth's 24-hour rota-tion.
📊
Key Findings & Data:In mammals, circadian integration of metabolic systems optimizes energy gathering and usage across the light and dark cycles.
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Conclusion & Impact:In this review, the mo-lecular and hormonal mechanisms behind obesity were discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Agouti-Related Protein (AgRP) · Endocrine · Gene Expression

Abstract

Most living organisms have circadian clocks which maintain rhythm in internal cycles of behavior, physiology, and metabolism, allowing them to anticipate the earth's 24-hour rota-tion. In mammals, circadian integration of metabolic systems optimizes energy gathering and usage across the light and dark cycles. Disruption of circadian rhythms may lead to metabolic dysfunctions such as obesity and obesity-related disorders. The molecular and hormonal mechanism behind obesity is mostly related to mRNA expressions in hypothala-mus, and leptin, and melatonin hormone levels. In obesity and related disorders, the chron-obiotic hormone melatonin regulates physiological functions such as energy metabolism, body fat, and reproduction by cross-interacting with leptin. Leptin signals satiety by inhibit-ing Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP genes in hypothalamus and exerts its effects on food intake, body weight, and the reproductive system. In this review, the mo-lecular and hormonal mechanisms behind obesity were discussed.

Özet

Çoğu canlı organizmanın, davranış, fizyoloji ve metabolizmanın iç döngülerinde ritmi koru-yan sirkadiyen saatleri vardır ve bu da organizmaların dünyanın 24 saatlik dönüşünü tahmin etmelerine olanak tanır. Memelilerde, metabolik sistemlerin sirkadiyen entegrasyonu, ışık ve karanlık döngüleri boyunca enerji toplanmasını ve kullanımını optimize eder. Sirkadiyen ritimlerin bozulması obezite ve obeziteye bağlı bozukluklar gibi metabolik işlev bozuklukla-rına yol açabilir. Obezitenin arkasındaki moleküler ve hormonal mekanizma çoğunlukla hi-potalamustaki mRNA ifadeleri ve leptin ve melatonin hormonlarının seviyeleriyle ilişkilidir. Obezite ve ilgili bozukluklarda kronobiyotik bir hormon olan melatonin, leptin ile çapraz etkileşime girerek enerji metabolizması, vücut yağı ve üreme gibi fizyolojik işlevleri düzen-ler. Leptin hormonu hipotalamustaki Nöropeptid Y/Agouti İlgili Peptid (NPY/AgRP) genle-rini inhibe ederek tokluk sinyali verir ve besin alımı, vücut ağırlığı ve üreme sistemi üzerin-de etkilerini gösterir. Bu derlemede obezitenin arkasındaki moleküler ve hormonal meka-nizmalar tartışılmıştır.

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Cite This Article

Gündüz, B., Balkan, E. İ. (2025). Melatonin - leptin interaction and obesity-related genes. Trakya University Journal of Natural Sciences, Volume: 26 Issue: 1. https://doi.org/10.23902/trkjnat.1619680

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