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Journals / Trakya University Journal of Natural Sciences / 2026 / Volume: 26 Issue: 1

Antiproliferative effect of silver compounds containing benzimidazole ring

Dilek Bahar(ERCİYES ÜNİVERSİTESİ)0000-0002-4916-5071
Senem Akkoç(SULEYMAN DEMIREL UNIVERSITY)0000-0002-1260-9425
Buket Banu Özkan(ERCIYES UNIVERSITY)0000-0002-1589-9464
Pages
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Publication Date
2025-04-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results revealed that the presence of drug candidates was more practical than that of commercially used cisplatin.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:With its significant biological activities, the benzimidazole nucleus is a crucial pharmacophore in medicine.
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Key Findings & Data:These complexes were cultured with lung (A549), colon (CaCo2), breast (MCF7), prostate (PC3) cancer cell lines, and healthy lung (WI38) cell line, and their anticancer effects were investigated through MTT, apoptosis determination, and oxidative stress tests.
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Conclusion & Impact:The results revealed that the presence of drug candidates was more practical than that of commercially used cisplatin.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Apoptosis · cytotoxic activity · Ag-NHC

Abstract

With its significant biological activities, the benzimidazole nucleus is a crucial pharmacophore in medicine. Recent studies have focused on the synthesis and biological activity of benzimidazole compounds. Therefore, this study prepared a series of N-heterocyclic silver compounds containing benzimidazole nuclei. These complexes were cultured with lung (A549), colon (CaCo2), breast (MCF7), prostate (PC3) cancer cell lines, and healthy lung (WI38) cell line, and their anticancer effects were investigated through MTT, apoptosis determination, and oxidative stress tests. The results revealed that the presence of drug candidates was more practical than that of commercially used cisplatin.

Özet

Benzimidazol çekirdeği önemli biyolojik aktiviteleri ile tıpta önemli bir farmakofordur. Son çalışmalar benzimidazol bileşiklerinin sentezi ve biyolojik aktivitesine odaklanmıştır. Bu nedenle, bu çalışmada benzimidazol çekirdekleri içeren bir dizi N-heterosiklik gümüş bileşiği hazırlamıştır. Bileşiklerin etkilerini incelemek için in vitro hücre kültür deneyleri yapılmıştır. Bileşikler akciğer (A549), kolon (CaCo2), meme (MCF7), prostat (PC3) kanser hücre hatları ve sağlıklı akciğer (WI38) hücre hattı ile kültüre edilmiş ve bileşiklerin antikanser etkileri bu hücreler üzerinde MTT hücre çoğalma testi, apoptoz tayini ve oksidatif stres testleri yapılarak araştırılmıştır. Sonuçlar ilaç adaylarının varlığının ticari olarak kullanılan sisplatinden daha pratik olduğunu ortaya koymuştur.

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Cite This Article

Bahar, D., Akkoç, S., Özkan, B. B. (2025). Antiproliferative effect of silver compounds containing benzimidazole ring. Trakya University Journal of Natural Sciences, Volume: 26 Issue: 1. https://doi.org/10.23902/trkjnat.1549105

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