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Journals / Mersin Üniversitesi Sağlık Bilimleri Dergisi / 2023 / Cilt: 16 Sayı: 3

The correlation between clinical prognosis together with the treatment of chronic Hepatitis B infection and Serum CD 95 (FAS) and Nitric Oxide levels in children

Çocukluk çağı kronik Hepatit B hastalığının klinik seyir ve tedavisi ile Serum CD 95 (FAS) ve Nitrik Oksid düzeyleri arasındaki ilişkinin belirlenmesi

Aylin Kont Özhan(MERSİN ÜNİVERSİTESİ)0000-0003-0486-0422
Mehmet Yavuz Çoşkun(GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6727-0070
Pages
495–502
Publication Date
2023-12-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Serum NO and CD 95 levels were found to increase in children with chronic inactive hepatitis B infection and in children with chronic active hepatitis B infection.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Nitric oxide (NO) and CD 95 (FAS) are thought to play a role in inflammation and apoptosis in chronic hepatitis B infections.
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Key Findings & Data:This study aimed to examine the serum NO and CD 95 levels of children with chronic hepatitis B infection in comparison with healthy children.
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Conclusion & Impact:Conclusion: Serum NO and CD 95 levels were found to increase in children with chronic inactive hepatitis B infection and in children with chronic active hepatitis B infection.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Hepatit B virüs · kronik hepatit B enfeksiyonu · apoptozis

Abstract

Aim: Nitric oxide (NO) and CD 95 (FAS) are thought to play a role in inflammation and apoptosis in chronic hepatitis B infections. This study aimed to examine the serum NO and CD 95 levels of children with chronic hepatitis B infection in comparison with healthy children. Method: 69 patients between the ages of 1 and 18 who were diagnosed with chronic hepatitis B were included in the study. 32 patients (21 boys, 11 girls) with chronic inactive hepatitis B infection as group 1, 37 patients with chronic active hepatitis B infection (25 boys, 12 girls) as group 2 and 32 healthy children (18 boys, 14 girls) as control group were included. Serum NO and CD 95 levels were measured. Comparisons between patient and control groups were made. Results: The mean age was 10.1±3.1 years in group 1, 9.3±3.3 years in group 2 and 9.2±1.8 years in the control group (p>0.05). Serum NO and CD 95 levels showed significant differences between the patient group and the control group (72.2±36.9 vs. 38.5±17.3 mµ, p 0.05). Conclusion: Serum NO and CD 95 levels were found to increase in children with chronic inactive hepatitis B infection and in children with chronic active hepatitis B infection.

Özet

Amaç: Nitrik oksid (NO) ve CD 95’ in (FAS) kronik hepatit B enfeksiyonlarında inflamasyonda ve apoptozisde rol oynadığı düşünülmektedir. Bu çalışmada, kronik hepatit B enfeksiyonu olan çocukların serum NO ve CD 95 düzeylerinin sağlıklı çocuklarla karşılaştırmalı olarak incelenmesi amaçlandı. Yöntem: Kronik hepatit B tanısı ile izlenen 1-18 yaş arası 69 hasta çalışmaya dahil edildi. Kronik inaktif hepatit B enfeksiyonu olan 32 hasta (21 erkek, 11 kız) grup 1 olarak, kronik aktif hepatit B enfeksiyonu olan 37 hasta (25 erkek, 12 kız) grup 2 olarak ve 32 sağlıklı çocuk (18 erkek, 14 kız) kontrol grubu olarak sınıflandırıldı. Serum NO ve CD 95 düzeyleri ölçüldü. Hasta ve kontrol grubu karşılaştırmaları yapıldı. Bulgular: Ortalama yaş grup 1’ de 10.1±3.1 yıl, grup 2’ de 9.3±3.3 yıl ve kontrol grubunda 9.2±1.8 yıl bulundu (p>0.05). Hasta grubu ve kontrol grubu arasında serum NO ve CD 95 düzeyleri anlamlı farklılık gösterdi (sırasıyla 72.2±36.9’a karşılık 38.5±17.3 mµ, p 0.05). Sonuç: Serum NO ve CD 95 düzeylerinin kronik inaktif hepatit B enfeksiyonu olan çocuklarda ve kronik aktif hepatit B enfeksiyonu olan çocuklarda artış gösterdiği saptanmıştır.

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Cite This Article

Özhan, A. K., Çoşkun, M. Y. (2023). The correlation between clinical prognosis together with the treatment of chronic Hepatitis B infection and Serum CD 95 (FAS) and Nitric Oxide levels in children. Mersin Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 16 Sayı: 3, 495–502. https://ajindex.com/articles/1109137

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