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Journals / Celal Bayar Üniversitesi Fen Bilimleri Dergisi / 2026 / Cilt: 21 Sayı: 2

Diagnostic Potential of miR-551b-3p in Lung Cancer: In Vitro and In Silico Experiments

Esen Çakmak(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ)0000-0002-9216-7478
İbrahim Seyfettin Çelik(KAHRAMANMARAS SUTCU IMAM UNIVERSITY)0000-0001-6946-4477
Pages
125–133
Publication Date
2025-06-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overexpression of miR-551b-3p and under expression of the ERBB4 gene decreased overall survival in cancer patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Lung cancer is a leading cause of cancer deaths worldwide. miRNAs have attracted attention as promising biomarkers in lung cancer diagnosis and prognosis.
📊
Key Findings & Data:This study investigated the molecular mechanism of miR-551b-3p in lung cancer cells.
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Conclusion & Impact:Overexpression of miR-551b-3p and under expression of the ERBB4 gene decreased overall survival in cancer patients.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:ERBB4 · Lung cancer · miR-551b-3p

Abstract

Lung cancer is a leading cause of cancer deaths worldwide. miRNAs have attracted attention as promising biomarkers in lung cancer diagnosis and prognosis. This study investigated the molecular mechanism of miR-551b-3p in lung cancer cells. The gene expression level of miR-551b-3p was investigated using qRT-PCR in healthy and cancerous lung cell lines. The target genes of miR-551b-3p and its function in cancer pathogenesis were also determined by in silico analyses. miR-551b-3p expression was higher in cancer cells compared to healthy lung cells (p<0.01). The expression level of miR-551b-3p was confirmed in silico in cancerous lung tissue. ERBB4 was identified as a target gene of miR-551b-3p and was down-regulated in cancer cells in comparison to healthy cells. Overexpression of miR-551b-3p and under expression of the ERBB4 gene decreased overall survival in cancer patients. A negative correlation was observed between miR-551b-3p and ERBB4 gene. miR-551b-3p expression was found to be closely associated with clinicopathological factors such as distant metastasis status, lymph node metastasis status and gender. miR-551b-3p target genes were enriched in cancer-related cellular processes. In conclusion, miR-551b-3p may be a potential alternative in treatment strategies as a therapeutic target in lung cancers.

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Cite This Article

Çakmak, E., Çelik, İ. S. (2025). Diagnostic Potential of miR-551b-3p in Lung Cancer: In Vitro and In Silico Experiments. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, Cilt: 21 Sayı: 2, 125–133. https://doi.org/10.18466/cbayarfbe.1582834

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