Journals / Celal Bayar Üniversitesi Fen Bilimleri Dergisi / 2026 / Cilt: 22 Sayı: 2

A Genetic Algorithm-Enhanced Method for Missing Value Imputation in Healthcare Datasets

Zeynep Orman(ISTANBUL UNIVERSITY-CERRAHPASA)0000-0002-0205-4198
Pages
225–235
Publication Date
2026-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Experimental results demonstrate the effectiveness of the proposed approach in managing missing data and addressing class imbalance, achieving performance close to or exceeding existing methodologies reported in the literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In healthcare datasets, imbalanced class distributions and missing data pose significant challenges to the performance and stability of machine learning models, thereby hindering accurate analysis and disease diagnosis.
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Key Findings & Data:Additionally, the framework incorporates the GASMOTEPSO_ENN method, which combines the Synthetic Minority Oversampling Technique (SMOTE) and Edited Nearest Neighbor (ENN) algorithms with GA and Particle Swarm Optimization (PSO) heuristics to effectively address class imbalance.
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Conclusion & Impact:Experimental results demonstrate the effectiveness of the proposed approach in managing missing data and addressing class imbalance, achieving performance close to or exceeding existing methodologies reported in the literature.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Disease classification · healthcare dataset · heuristic approach

Abstract

In healthcare datasets, imbalanced class distributions and missing data pose significant challenges to the performance and stability of machine learning models, thereby hindering accurate analysis and disease diagnosis. Addressing these challenges is crucial for improving both the precision and reliability of healthcare data analysis. This paper proposes a novel preprocessing framework specifically designed for healthcare datasets to mitigate issues related to incomplete data and class imbalance. The framework introduces a new imputation method, GA-MICE, which enhances the Multiple Imputation by Chained Equations (MICE) technique using a Genetic Algorithm (GA) to improve the accuracy of handling missing data. Additionally, the framework incorporates the GASMOTEPSO_ENN method, which combines the Synthetic Minority Oversampling Technique (SMOTE) and Edited Nearest Neighbor (ENN) algorithms with GA and Particle Swarm Optimization (PSO) heuristics to effectively address class imbalance. After preprocessing, six machine learning classifiers are employed to categorize individuals as either patients or healthy subjects. The model's performance is evaluated using multiple metrics, including accuracy, precision, recall, F1-score, Matthews Correlation Coefficient (MCC), and Area Under the Curve (AUC). Experimental results demonstrate the effectiveness of the proposed approach in managing missing data and addressing class imbalance, achieving performance close to or exceeding existing methodologies reported in the literature.

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Cite This Article

Özoğur, H. N., Orman, Z. (2026). A Genetic Algorithm-Enhanced Method for Missing Value Imputation in Healthcare Datasets. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, Cilt: 22 Sayı: 2, 225–235. https://doi.org/10.18466/cbayarfbe.1766229

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