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Journals / Celal Bayar Üniversitesi Fen Bilimleri Dergisi / 2026 / Cilt: 22 Sayı: 3

Synthesis, Antioxidant and Antibacterial Potentials of Schiff Base Derivatives Containing Hydroxy Groups: Molecular Docking and ADME Approaches

Özlem Gündoğdu(KIRSEHIR AHI EVRAN UNIVERSITY)0000-0002-6943-9674
Sertan Aytaç(KIRSEHIR AHI EVRAN UNIVERSITY)0000-0002-3196-4545
Kübra Öztürk(KIRSEHIR AHI EVRAN UNIVERSITY)0000-0002-4488-0164
Çiğdem Er Çalışkan(KIRSEHIR AHI EVRAN UNIVERSITY)0000-0001-5821-7489
Pages
568–601
Publication Date
2026-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Antibacterial results indicated clear differences between Gram-positive and Gram-negative bacteria; notably, compound 10 was highly active against Acinetobacter baumannii, exceeding gentamicin (GN) and ciprofloxacin (CIP).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, hydroxyl-containing Schiff base derivatives (7-11) were synthesized and confirmed by detailed spectroscopic analyses.
📊
Key Findings & Data:In Fe³⁺ and Cu²⁺ reduction assays, compound 7 showed the highest Fe³⁺ reducing capacity, while compound 8 exhibited the strongest Cu²⁺ reduction.
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Conclusion & Impact:Antibacterial results indicated clear differences between Gram-positive and Gram-negative bacteria; notably, compound 10 was highly active against Acinetobacter baumannii, exceeding gentamicin (GN) and ciprofloxacin (CIP).
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Hydroxyl groups · Schiff Base · Antioxidant

Abstract

In this study, hydroxyl-containing Schiff base derivatives (7-11) were synthesized and confirmed by detailed spectroscopic analyses. The antioxidant and antibacterial potentials of the synthesised compounds were evaluated. In Fe³⁺ and Cu²⁺ reduction assays, compound 7 showed the highest Fe³⁺ reducing capacity, while compound 8 exhibited the strongest Cu²⁺ reduction. In the DPPH assay, compound 8 was the most potent, with the lowest IC₅₀ value (12.24 μg/mL). In ABTS, compound 7 showed greater reducing activity than Trolox. Antibacterial results indicated clear differences between Gram-positive and Gram-negative bacteria; notably, compound 10 was highly active against Acinetobacter baumannii, exceeding gentamicin (GN) and ciprofloxacin (CIP). Molecular docking and ADME analyses further supported the findings by showing strong binding to target proteins and good drug-like properties. Overall, the derivatives demonstrated remarkable biological potential, especially antioxidant and antimicrobial activities.

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Cite This Article

Gündoğdu, Ö., Aytaç, S., Öztürk, K., Çalışkan, Ç. E. (2026). Synthesis, Antioxidant and Antibacterial Potentials of Schiff Base Derivatives Containing Hydroxy Groups: Molecular Docking and ADME Approaches. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, Cilt: 22 Sayı: 3, 568–601. https://doi.org/10.18466/cbayarfbe.1922710

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