SavedAdd your journal

Journals / Harran Üniversitesi Tıp Fakültesi Dergisi / 2015 / Cilt: 12 - Sayı: 1

Central nervous system complications in hemophagocytic lymphohistiocytosis

Hemofagositik lenfohistiositozda santral sinir sistemi komplikasyonları

Mervan BEKDAŞ
Sevil Bilir GÖKSÜGÜR
Fatih DEMİRCİOĞLU
Pages
154–164
Publication Date
2015-04-15
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, we wanted to attract attention to the picture of the central nervous system involvement as a result of hemophagocytic lymphohistiocytosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hemophagocytic lymphohistiocytosis is a rare disease, affecting multiple systems.
📊
Key Findings & Data:Central nervous system involvement is very important because of the effect on the prognosis.
💡
Conclusion & Impact:In this article, we wanted to attract attention to the picture of the central nervous system involvement as a result of hemophagocytic lymphohistiocytosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hemofagositik lenfohistiositoz · çocuk · santral sinir sistemi

Abstract

Hemophagocytic lymphohistiocytosis is a rare disease, affecting multiple systems. Central nervous system involvement is very important because of the effect on the prognosis. Arising neurological symptoms as a result of this involvement are included in some publications, but the number of publications related to their frequency, characteristics, and relations with morbidity and mortality is rare. In this article, we wanted to attract attention to the picture of the central nervous system involvement as a result of hemophagocytic lymphohistiocytosis.

Özet

Hemofagositik lenfohistiositoz, çok sayıda sistemi etkileyen, nadir görülen bir hastalıktır. Santral sinir sistemi tutulumu, prognozu etkilemesi ve ciddi sekel oluşturma riski nedeniyle çok önemlidir. Hemofagositik lenfohistiositozun santral sinir sistemi tutulumu ilişkili nörolojik bulgu ve komplikasyonların sıklıkları, özellikleri, morbidite ve mortaliteye etkisini irdeleyen yayın sayısı azdır. Bu yazıda, hemofagositik lenfohistiositozun santral sinir sistemi tutulumu ile ilişkili klinik tabloya dikkat çekmek istedik.

🔖

Cite This Article

BEKDAŞ, M., GÖKSÜGÜR, S. B., DEMİRCİOĞLU, F. (2015). Central nervous system complications in hemophagocytic lymphohistiocytosis. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 12 - Sayı: 1, 154–164. https://ajindex.com/articles/108559

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Imashuku S, Teramura T, Morimoto A, et al. Recent developments in the management of haemophagocytic lymphohistiocytosis. Expert Opin Pharmacother 2001
  2. 48 2)Imashuku S, Hibi S, Sako M, et al. Soluble interleukin2 receptor: a useful prognostic factor for patients with hemophagocytic lymphohistiocytosis. Blood 1995, 86:4706-7 1) 3)Ravelli A: Macrophage activation syndrome. Curr Opin Rheumatol 2002
  3. 52 4)Osugi Y, Hara J, Tagawa S, et al. Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis. Blood 1997
  4. 3 5)Teruya-Feldstein J, Setsuda J, Yao X, et al. MIP-1 expression in tissues from patients with h emo p h a g o c y ti c s y n d r ome. La b I n v e st 1999
  5. 90 6)Schneider EM, Lorenz I, Müller-Rosenberger M, et al. Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer-cellinducedapoptosis. Blood 2002
  6. 8 7)Janka GE, Schneider EM. Modern management of children with haemophagocytic lymphohistiocytosis. Br J Haematol 2004
  7. 14 8)Janka GE: Hemophagocytic syndromes. Blood Rev 2007
  8. 53 9)Henter JI, Elinder G. Incidence in Sweden and clinical f e a t u r e s o f f a m i l i a l h e m o p h a g o c y t i c lymphohistiocytosis. Acta Paediatr Scand 1991
  9. 35 10)Gurgey A, Gogus S, Ozyurek E et al. Primary hemophagocytic lymphohistiocytosis in Turkish children. Pediatr Hematol Oncol 2003
  10. 367–71 11)Behrens EM, Canna SW, Slade K, et al: Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 2011
  11. De Saint Basile G, Fischer A. Defective cytotoxic granule-mediated cell death pathway impairs T lymphocyte homeostasis. Curr Opin Rheumatol 2003
  12. 45 13)Zhang K, Jordan MB, Marsh RA, et al: Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial hemophagocytic lymphohistiocytosis. Blood 2011
  13. 98 14)Clementi R, Emmi L, Maccario R, et al. Adult onset and atypical presentation of hemophagocytic lymphohistiocytosis in siblings carrying PRF1 mutations. Blood 2002
  14. 67 15)Ansuini V, Rigante D, Esposito S. Debate around infection- dependent hemophagocytic syndrome in paediatrics. BMC Infectious Diseases 2013
  15. 23 16)Henter JI, Ehrnst A, Andersson J, Elinder G. Familial hemophagocytic lymphohistiocytosis and viral infections. Acta Paediatr 1993
  16. 72 17)Rajagopala S, Singh N. Di