Journals / Harran Üniversitesi Tıp Fakültesi Dergisi / 2009 / Cilt: 6 Sayı: 1

Acute Isoniazid Poisoning Presenting With Convulsions And Coma

Koma Ve Konvülziyon İle Getirilen Akut İzoniazid Zehirlenmesi

Alpay Cakmak(Department of Pediatrics, Harran University School of Medicine)
Ali Atas(Department of Pediatrics, Harran University School of Medicine)
Mustafa Soran(Department of Pediatrics, Harran University School of Medicine)
Dost Zeyrek(Department of Pediatrics, Harran University School of Medicine)
Pages
47–48
Publication Date
2009-04-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Parenteral pyridoxine administration is an effective method in isoniazid intoxication

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: We report a case of acute isoniazid intoxication presented with convulsions, and coma.
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Key Findings & Data:Case: An 8-year-old boy had taken 10 isoniazid tablets 100mg/tb which had been started as a prophylactic.
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Conclusion & Impact:Parenteral pyridoxine administration is an effective method in isoniazid intoxication
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Konvülziyon · İsoniazid · Zehirlenme

Abstract

Purpose: We report a case of acute isoniazid intoxication presented with convulsions, and coma. Case: An 8-year-old boy had taken 10 isoniazid tablets 100mg/tb which had been started as a prophylactic. A nasogastric catheter was administered and gastric lavage was performed followed by the administration of activated charcoal. Immediately after the procedure, sudden convulsions began, which subsided within five minutes of the administration of diazepam infusion. As an antidote, Pyridoxine 1.5 gr 50 mg/kg/day ,was administered intravenously. After 8 hours the patient regained consciousness, his general condition normalized and oral nutrition was started. Conclusions: Pyridoxine administration is the best way of treating convulsions. Parenteral pyridoxine administration is an effective method in isoniazid intoxication

Özet

Amaç: Konvülziyon ve koma ile gelen akut izoniazid zehirlenmesi olan olguyu sunmak amaçlandı. Olgu: Proflaksi amaçlı başlanan izoniazid tabletlerden 100mg/tb 10 tane alan 8 yaşındaki erkek olgu sunuldu. Beslenme sondası aracılığı ile olguya mide lavajı yapıldı. Mide lavajı sonrasında olguya aktif kömür uygulandı. Acile getirildiği sırada konvülzyonu başlayan olguya diazepam uygulandı ve konvülzyonu 5. dakikada durdu. Antidot olarak Pridoksin 1.5 gr 50 mg/kg/gün intravenöz olarak uygulandı. 8 saatlik takip sonrası hastanın bilinci açıldı. Genel durumu düzeldi. Oral beslenmeye başladı Sonuç: İzoniazid zehirlenmesinde konvülziyonun tedavisinde en iyi yol Pridoksin uygulanmasıdır

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Cite This Article

Cakmak, A., Atas, A., Soran, M., Zeyrek, D. (2009). Acute Isoniazid Poisoning Presenting With Convulsions And Coma. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 6 Sayı: 1, 47–48. https://ajindex.com/articles/1081835

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References (8)

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  6. Corresponding Address: Alpay Cakmak, MD Harran University School of Medicine Department of Pediatrics TR-63100, Sanliurfa, TURKEY. Tel: +90 414 3141170 Mobile Phone: +90 5326235956 e-mail: [email protected] Fax: +90 414 3151181
  7. Romero JA, Kuczler FJ. Isoniazid overdose. Recognition and management. Am Fam Physician; 57: 749-752. Miller J, Robinson A, Percy AK. Acute isoniazid poisoning in childhood. Am J Dis Child; 134: 290-292. Ozmenoglu M, Bolukbası O, Mocan H, Bulut F. Acute Isoniazid Poisoning Presenting As Seizures.;31:63-65. Turkmen A, Ersoy A, Atlan A, Turgut N, Ervatan Z, Kızılırmak S. Acute isoniaside intoxication.;20:51-53
  8. Corresponding Address: Alpay Cakmak, MD Harran University School of Medicine Department of Pediatrics TR-63100, Sanliurfa, TURKEY. Tel: +90 414 3141170 Mobile Phone: +90 5326235956 e-mail: [email protected] Fax: +90 414 3151181