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Journals / Harran Üniversitesi Tıp Fakültesi Dergisi / 2014 / Cilt: 11 Sayı: 3

Assessment Of Mean Platelet Volume In Patients Deficiency Vitamin B12

Vitamin B12 Eksiliğinde Hastalarda Ortalama Trombosit Volümün Değerlendirilmesi

Mahmut Abuhandan
Hüseyin Gümüş
Abdullah Solmaz
Bülent Güzel
Pages
253–256
Publication Date
2014-12-15
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: This study suggests that for the diagnosis of patients with vitamin B12 deficiency may be indication by looking the values of mean platelet volume in routine complete blood count. 

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectıve: In this study, we aimed to evaluate mean Platelet Volume (MPV) at children with vitamin B12 deficiency.
📊
Key Findings & Data:Material and method: 68 patients with the diagnosis of vitamin B12 deficiency and 54 healthy children as a control group were enrolled to study.
💡
Conclusion & Impact:Conclusions: This study suggests that for the diagnosis of patients with vitamin B12 deficiency may be indication by looking the values of mean platelet volume in routine complete blood count. 
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Çocuk · Vitamin B12 · Ortalama trombosit volümü

Abstract

Objectıve: In this study, we aimed to evaluate mean Platelet Volume (MPV) at children with vitamin B12 deficiency. Material and method: 68 patients with the diagnosis of vitamin B12 deficiency and 54 healthy children as a control group were enrolled to study. MPVand platelet counts were evaluated at patients and control groups. Vitamin B12 level under of 200 pg / Lwere considered to be insufficiency. Results: İn the study vitamin B12 deficiency patients of mean platelet volume values compared to the healthy (7.09 ± 1.1 fl) control group (6.52 ± 0.7 fl) was statistically significantly higher mean values (p=0.001), and platelet count were not statistically significant (p> 0.05). Conclusions: This study suggests that for the diagnosis of patients with vitamin B12 deficiency may be indication by looking the values of mean platelet volume in routine complete blood count. 

Özet

Amaç: Bu çalışmada vitamin B12 eksiliği olan çocuklarda Ortalama Trombosit Volümünün değerlendirilmesi amaçlandı. Metaryal ve metod: Vitamin B eksikliği tanısı alan 68 hasta ile 54 sağlıklı kontrol grubu çalışmaya alındı. 12 Hasta ve kontrol grubunun Ortalama Trombosit Volümü ve trombosit sayıları değerlendirildi. Vitamin B12 düzeyi 200 pg/Laltında eksiklik olarak kabul edildi. Bulgular: Çalışmaya alınan vitamin B eksikliği olan hastaların ortalama trombosit volümü değerleri (7.09 12 ± 1.1 fl) ile sağlıklı kontrol grubun ortalama değerleri (6.52 ± 0.7 fl) karşılaştırıldığında istatistiksel olarak anlamlı derecede yüksek bulunurken (p=0.001), trombosit sayısı açısında istatistiksel olarak anlamlı bir fark bulunmadı (p>0.05). Sonuç: Rutin tam kan sayımında ortalama trombosit volümü değerlerine bakarak vitamin B eksikliği 12 yakalanmasının mümkün olabileceğini düşündürmektedir.

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Cite This Article

Abuhandan, M., Gümüş, H., Solmaz, A., Güzel, B. (2014). Assessment Of Mean Platelet Volume In Patients Deficiency Vitamin B12. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 11 Sayı: 3, 253–256. https://ajindex.com/articles/1081716

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  30. Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, et al. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab, 1999. 67(4): 317-23
  31. Roschitz B, Plecko B, Huemer M, ark. Nutritional infantile vitamin B12 deficiency: pathobiochemical considerations in seven patients. Arch Dis Child Fetal Neonatal Ed 2005;90:281-2
  32. Brocadello F, Levedianos G, Piccione F, Manara R, Pesenti FF. Irreversible subacute sclerotic combined degeneration of the spinal cord in a vegan subject. Nutrition 2007;23(7-8):622-4
  33. Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson BL, Ratliff TL. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity. 2003;19(1):9-19 6) Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996; 7(2):157-61
  34. Sharp DS, Benowitz NL, Bath PM, Martin JF, Beswick AD, Elwood PC. Cigarette smoking sensitizes and desensitizes impedance-measured ADP-induced platelet aggregation in whole blood. Thromb Haemost. 1995; 74(2):730-5
  35. Uysal P, Tuncel T, Olmez D, Babayigit A, Karaman O, Uzuner N. The role of mean platelet volume predicting acute exacerbations of cystic fibrosis in children. Ann Thorac Med. 2011; 6(4): 227-30
  36. Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, Abayli E, Altiparmak E. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20(4): 277-81
  37. Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, Ataoglu S. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets. 2010; 21(2): 122-5
  38. Makay B, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009; 28(8): 975-8
  39. Oncel MY, Ozdemir R, Yurttutan S, Canpolat FE, Erdeve O, Oguz SS, Uras N, Dilmen U. Mean platelet volume in neonatal sepsis. J Clin Lab Anal. 2012; 26(6): 493-6
  40. Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S, Cengiz AB, Ceyhan M. The value of mean platelet volume in the determination of community acquired pneumonia in children. Ital J Pediatr. 2013; 8;39:16
  41. Catal F, Bavbek N, Bayrak O, Uz E, Isik B, Karabel M, Degirmencioglu H, Mete E, Akcay A. Platelet parameters in children with upper urinary tract infection: is there a specific response? Ren Fail. 2008;30(4):377-81
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  44. Toh BH, van Driel IR, Gleeson PA. Pernisious anemia. N Eng J Med. 1997;337:1441-1448
  45. Zaki MM. Parasite Platelet Interactions. PUJ; 2011, 4(2): 127-136
  46. Flad, HD, Brandt E. Platelet-derived chemokines: Pathophysiology and therapeutic aspects. Cell Mol Life Sci; 2010, 67 (14):2363-86
  47. Tschoepe D, Roesen P, Esser J, Schwippert B, Nieuwenhuis HK, Kehrel B, Gries FA. Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost. 1991;17(4):433-8
  48. Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J. 2008; 49(2):114-6
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  50. Ghahremanfard F, Asghari N, Ghorbani R, Samaei A, Ghomi H, Tamadon M. The relationship between mean platelet volume and severity of acute ischemic brain stroke. Neurosciences (Riyadh). 2013;18(2):147-51
  51. Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol. 1992;14(4):281-7
  52. Bath PM, Missouris CG, Buckenham T, MacGregor GA. Increased platelet volume and platelet mass in patients with atherosclerotic renal artery stenosis. Clin Sci (Lond). 1994;87(2):253-7
  53. Icli A, Aksoy F, Dogan A, Arslan A, Akcay S, Yücel H, Ersoy I, Gorgulu O. Increased Mean Platelet Volume in Hypertrophic Cardiomyopathy. Angiology. 2013. [Epub ahead of print] PubMed PMID: 23564022
  54. Oztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N, Aydinli M, Kadayifci A, Kepekci Y. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci. 2013;17(3):334-41
  55. Liu R, Gao F, Huo J, Yi Q. Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease. Platelets. 2012;23(1):11-6
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