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Journals / Harran Üniversitesi Tıp Fakültesi Dergisi / 2026 / Cilt: 21 Sayı: 1

Plasma Free Amino Acid and Carnitine Levels in Pregnant Women with Hydatidiform Mole: A Case-Controlled Study

Hidatidiform Mol Gebeliği olan Kadınlarda Plazma Serbest Amino Asit ve Karnitin Düzeyleri: Vaka Kontrol Çalışması

Hacer Uyanikoglu(Harran Üniversitesi Tıp Fakültesi)0000-0003-0316-4900
İsmail Koyuncu(HARRAN UNIVERSITY)0000-0002-9469-4757
Sibel Sak(HARRAN ÜNİVERSİTESİ)0000-0001-7401-3945
Mehmet Emin Tasduzen(HARRAN ÜNİVERSİTESİ)0000-0002-8529-3089
Ataman Gönel(HARRAN ÜNİVERSİTESİ)0000-0001-7200-1537
Muhammet Erdal Sak(HARRAN UNIVERSITY)0000-0002-6570-1057
Mert Ulaş Barut(HARRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7008-8218
Pages
131–137
Publication Date
2024-04-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: To determine plasma free amino acid (FAA) and carnitine levels in pregnant women with hydatidiform mole (HM).
📊
Key Findings & Data:Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study.
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Conclusion & Impact:Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:karnitin · serbest amino asit · gebelik

Abstract

Background: To determine plasma free amino acid (FAA) and carnitine levels in pregnant women with hydatidiform mole (HM). Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study. FAA and carnitine concentrations were measured in plasma using liquid chromatography/tandem mass spectrometry (LC-MS). Results: The levels of alanine, arginine, and valine from the 14 amino acids examined were signif-icantly lower in the HM group than in the healthy group (p = 0.019, p = 0.009, and p = 0.03, respec-tively). In addition, several carnitines, C8DC, C16:1, and C18, of the 27 carnitines examined were significantly higher in the HM group than in the control group (p = 0.021, p = 0.03, and p = 0.021, respectively). Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.

Özet

Amaç: Hidatidiform mol (HM)'li gebe kadınlarda plazma serbest amino asit (FAA) ve karnitin düzeylerini belirlemek. Materyal ve metod: Çalışmaya 23 HM'li gebe ve kontrol grubu olarak 24 sağlıklı gebe dahil edildi. FAA ve karnitin konsantrasyonları, sıvı kromatografisi/tandem kütle spektrometrisi (LC-MS) kullanılarak plazmada ölçüldü. Bulgular: İncelenen 14 amino asitten alanin, arginin ve valin düzeyleri HM grubunda sağlıklı gruba göre anlamlı derecede düşüktü (sırasıyla p = 0,019, p = 0,009 ve p = 0,03). Ek olarak, incelenen 27 karnitinden birkaç karnitin, C8DC, C16:1 ve C18, HM grubunda kontrol grubuna göre önemli ölçüde daha yüksekti (sırasıyla p = 0,021, p = 0,03 ve p = 0,021). Sonuç: Bu çalışma, bazı FAA'lerin plazma seviyesindeki azalmanın ve bazı karnitinlerin de plazma düzeylerindeki artışın HM patogenezinde etkili olabileceğini ortaya koydu.

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Cite This Article

Uyanikoglu, H., Koyuncu, İ., Sak, S., Tasduzen, M. E., Gönel, A., Sak, M. E., Barut, M. U. (2024). Plasma Free Amino Acid and Carnitine Levels in Pregnant Women with Hydatidiform Mole: A Case-Controlled Study. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 21 Sayı: 1, 131–137. https://doi.org/10.35440/hutfd.1381095

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