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Journals / Harran Üniversitesi Tıp Fakültesi Dergisi / 2025 / Cilt: 22 Sayı: 3

Effect of Vitamin D Deficiency on Peripapillary Retinal Nerve Fiber Layer and Choroidal Thickness: A Cross-Sectional Study

D Vitamini Eksikliğinin Peripapiller Retina Sinir Lifi Tabakası ve Koroid Kalınlığı Üzerindeki Etkisi: Kesitsel Bir Çalışma

Burak Ören(Department of Ophthalmology, School of Medicine, Adiyaman University, Adiyaman, Turkey)0000-0003-4933-2500
Özhan Uygun(Private NCR İnternational Hospital, Department of ˙Internal Medicine, Gaziantep, Turkey)0000-0002-6317-0408
Pages
515–521
Publication Date
2025-09-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, VDD may cause choroidal pathologies.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: To evaluate the effect of vitamin D deficiency (VDD) on the choroidal thickness (CT) and the peripapillary retinal nerve fiber layer thickness (RNFLT).
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Key Findings & Data:Materials and Methods: This study involved 60 patients with VDD (Group 1) and 50 healthy controls (Group 2).
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Conclusion & Impact:Therefore, VDD may cause choroidal pathologies.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:D Vitamini Eksikliği · Koroid Kalınlığı · Retina Sinir Lifi Tabakası

Abstract

Background: To evaluate the effect of vitamin D deficiency (VDD) on the choroidal thickness (CT) and the peripapillary retinal nerve fiber layer thickness (RNFLT). Materials and Methods: This study involved 60 patients with VDD (Group 1) and 50 healthy controls (Group 2). Group 1 was further divided into three subgroups—severe deficiency (Group 1a), defici-ency (Group 1b), and insufficiency (Group 1c)—based on serum vitamin D levels. Optical coherence tomography (OCT) was utilized to measure the subjects’ subfoveal CT, nasal CT, temporal CT, and peripapillary RNFLT. Results: The subfoveal, temporal, and nasal CTs were observed to be significantly thinner in Group 1 than in Group 2 (p < 0.001). However, peripapillary RNFLTs did not differ significantly between Groups 1 and 2 in all quadrants (all p > 0.05). Subfoveal, temporal, and nasal CTs were significantly thinner in Group 1a than in Groups 1b and 1c (all p < 0.001). However, peripapillary RNFLTs were comparable across subgroups in all quadrants (all p > 0.05). Vitamin D levels correlated positively with subfoveal, temporal, and nasal CTs among patients with VDD. Conclusions: Patients with VDD exhibited decreased CTs, and those with severe deficiency showed an even more dramatic decrease. Therefore, VDD may cause choroidal pathologies.

Özet

Amaç: D vitamini eksikliğinin (DVE) koroid kalınlığı (KK) ve peripapiller retina sinir lifi tabakası kalınlığı (RSLTK) üzerindeki etkisini değerlendirmek. Materyal ve Metod: Çalışma grubu, DVE'si olan 60 hastadan (Grup 1) ve 50 sağlıklı kontrolden (Grup 2) oluşuyordu. Alt gruplama için serum D vitamini düzeyleri kriter alınarak Grup 1'den şiddetli eksi-klik (Grup 1a), eksiklik (Grup 1b) ve yetersizlik (Grup 1c) olmak üzere üç alt grup oluşturuldu. Deneklerin subfoveal, nazal, temporal KK ve peripapiller RSLTK'sini ölçmek için optik koherens to-mografi (OKT) (Heidelberg Spectralis OKT) kullanıldı. Bulgular: Grup 1'in subfoveal, temporal ve nazal KK ölçümlerinin Grup 2'ninkinden önemli ölçüde daha ince olduğu görüldü (p<0,001). Grup 1 ve Grup 2'nin tüm kadranlarda Peripapiller RSLTK'leri benzerdi (her biri için p>0,05). Subfoveal, temporal ve nazal KK ölçümleri Grup 1a'da Grup 1b ve Grup 1c'den önemli ölçüde daha inceydi (her biri için p<0,001). Alt grupların peripapiller RSLTK'leri tüm kadranlarda benzerdi (her biri için p>0,05). DVE'li hastalarda subfoveal KK, temporal KK ve nazal KK skorları ile D vitamini seviyeleri arasında pozitif korelasyonlar bulundu. Sonuç: DVE'li hastalarda KK'de azalma izlendi ve şiddetli eksikliği olanlarda daha da belirgin bir azalma mevcuttu. DVE koroidal patolojilere neden olabilir.

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Cite This Article

Ören, B., Uygun, Ö., *, B. Ö. (2025). Effect of Vitamin D Deficiency on Peripapillary Retinal Nerve Fiber Layer and Choroidal Thickness: A Cross-Sectional Study. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 22 Sayı: 3, 515–521. https://doi.org/10.35440/hutfd.1696683

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