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Journals / Harran Üniversitesi Tıp Fakültesi Dergisi / 2026 / Cilt: 23 Sayı: 2

Determinants of Treatment Failure and Recurrence in Scabies: A Single-Center Retrospective Study of 332 Cases

Skabiyeste Tedavi Başarısızlığı ve Nüksün Belirleyicileri: 332 Olgunun Tek Merkezli Retrospektif Analizi

Mustafa Uğuz(Mersin Şehir Eğitim ve araştırma Hastanesi)0000-0002-3428-6137
Berfin Çirkin Doruk(Mersin Şehir Eğitim ve Araştırma Hastanesi)0000-0002-5370-4197
Kenan Yıldız(Medical Park)0000-0002-9190-6136
Pages
235–241
Publication Date
2026-06-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Standardization of household contact management and improvement of patient adherence represent key strategies for reducing treatment failure.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: This study aimed to identify the main determinants of treatment failure in scabies, with particular emphasis on the role of household treatment compliance and contact management.
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Key Findings & Data:Materials and Methods: Between January 2023 and October 2025, a total of 332 patients diagnosed with scabies clinically and/or dermoscopically in a dermatology outpatient clinic were retrospectively analyzed.
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Conclusion & Impact:Standardization of household contact management and improvement of patient adherence represent key strategies for reducing treatment failure.
🔬Design:Araştırma Makalesi
📍Scope:2023 Verileri
⚙️Variables:Skabiyez · Permetrin · Tedavi Başarısızlığı

Abstract

Background: This study aimed to identify the main determinants of treatment failure in scabies, with particular emphasis on the role of household treatment compliance and contact management. Materials and Methods: Between January 2023 and October 2025, a total of 332 patients diagnosed with scabies clinically and/or dermoscopically in a dermatology outpatient clinic were retrospectively analyzed. Demographic characteristics, contact history, household treatment status, and factors associated with treatment failure were evaluated. The causes of treatment failure were classified, and the association between household treatment status and failure types was analyzed using the chi-square test. Results: Of the patients, 78.9% were adults and 55.4% were male. The most frequent cause of treatment failure was incomplete or absent household treatment (58.4%), followed by clinically suspected permethrin non-response (16.9%), reinfestation (12.7%), and incorrect or insufficient treatment (12.0%). A statistically significant association was observed between household treatment status and the distribution of treatment failure types (χ²=222.8; p<0.001). Conclusions: Treatment failure in scabies is primarily associated with inadequate simultaneous household treatment and ongoing intra-household transmission rather than pharmacological resistance. Standardization of household contact management and improvement of patient adherence represent key strategies for reducing treatment failure.

Özet

Amaç: Bu çalışmada, skabiyeste tedavi başarısızlığının temel belirleyicilerinin belirlenmesi ve özellikle hane içi tedavi uyumu ile temas yönetiminin klinik sonuçlar üzerindeki etkisinin değerlendirilmesi amaçlandı. Materyal ve metod: Ocak 2023 - Ekim 2025 tarihleri arasında dermatoloji polikliniğinde klinik ve/veya dermoskopik olarak skabies tanısı alan toplam 332 hasta retrospektif olarak incelendi. Demografik özellikler, temas öyküsü, hane içi tedavi durumu ve tedavi başarısızlığı ile ilişkili faktörler değerlendirildi. Tedavi başarısızlığı nedenleri sınıflandırıldı ve hane içi tedavi durumu ile başarısızlık tipleri arasındaki ilişki ki-kare testi ile analiz edildi. Bulgular: Hastaların %78,9’u erişkin, %55,4’ü erkekti. Tedavi başarısızlığının en sık nedeni hane içi tedavinin eksik veya hiç uygulanmaması (%58,4) olup, bunu klinik olarak şüpheli permetrin tedavi yanıtsızlığı (%16,9), yeniden bulaş (%12,7) ve hatalı veya yetersiz tedavi (%12,0) izledi. Hane içi tedavi durumu ile tedavi başarısızlığı tipleri arasında istatistiksel olarak anlamlı ilişki saptandı (χ²=222,8; p<0,001). Sonuç: Skabiyeste tedavi başarısızlığı, farmakolojik dirençten ziyade yetersiz eş zamanlı hane içi tedavi ve devam eden hane içi bulaş ile ilişkilidir. Hane içi temas yönetiminin standardize edilmesi ve hasta uyumunun artırılması, tedavi başarısızlığının azaltılmasında temel stratejilerdir.

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Cite This Article

Uğuz, M., Doruk, B. Ç., Yıldız, K. (2026). Determinants of Treatment Failure and Recurrence in Scabies: A Single-Center Retrospective Study of 332 Cases. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 23 Sayı: 2, 235–241. https://doi.org/10.35440/hutfd.1860261

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References (20)

  1. Taş Demircan Y, Yıldız K, Elibüyük Akkaç S, Öztürk M. Epidemiological features of scabies cases in Adana region of Turkey: Cross-sectional study. Turkiye Klinikleri J Dermatol. 2021;31(3):163-7.
  2. Vasanwala FF, Ong CY, Aw CWD, How CH. Management of scabies. Singapore Med J. 2019;60(6):281-5.
  3. World Health Organization. Scabies: Key facts. Geneva: World Health Organization; 2023. Available from: https://www.who.int/health-topics/scabies
  4. Karimkhani C, Colombara DV, Drucker AM, Norton SA, Hay R, Engelman D, et al. Global burden of scabies: a cross-sectional analysis from the Global Burden of Disease Study 2015. Lancet Infect Dis. 2017;17(12):1247-54.
  5. Schneider S, Wu J, Tizek L, Ziehfreund S, Zink A. Prevalence of scabies worldwide—An updated systematic literature review in 2022. J Eur Acad Dermatol Venereol. 2023;37(9):1749-57.
  6. Aktaş H, Cebecik A. Changes in incidence and age distribution of scabies: A retrospective cohort study in a tertiary hospital. Arch Clin Exp Med. 2019;4(1):21-4.
  7. Özden MG, Ertürk K, Kartal SP, Yaylı S, Göktay F, Doğramacı C, et al. An extraordinary outbreak of scabies in Turkey. J Eur Acad Dermatol Venereol. 2020;34(12):e818-20.
  8. Uzun S, Durdu M, Yürekli A, Mülayim MK, Akyol M, Velipaşaoğlu S, et al. Clinical practice guidelines for the diagnosis and treatment of scabies. Int J Dermatol. 2024;63(12):1642-56.
  9. Balestri R, Magnano M, Infusino SD, Rizzoli L, Girardelli CR, Rech G. Use of oral ivermectin in permethrin-resistant scabies: A pilot study. Dermatol Ther. 2022;35(6):e15495.
  10. Mbuagbaw L, Sadeghirad B, Morgan RL, Mertz D, Motaghi S, Ghadimi M, et al. Failure of scabies treatment: A systematic review and meta-analysis. Br J Dermatol. 2024;190(2):163-73.
  11. Morris G, Haddow L, Sashidharan PN, Savary-Trathen A, Soni S, Bigland C, et al. British Association for Sexual Health and HIV National Guideline on the Management of Scabies in adults 2025. Int J STD AIDS. 2025;36(7).
  12. Engelman D, Yoshizumi J, Hay RJ, Osti M, Micali G, Norton S, et al. The 2020 International Alliance for the Control of Scabies consensus criteria for the diagnosis of scabies. Br J Dermatol. 2020;183(5):808-20.
  13. Lake SJ, Kaldor JM, Hardy M, Engelman D, Steer AC, Romani L. Mass drug administration for the control of scabies: a systematic review and meta-analysis. Clin Infect Dis. 2022;75(6):959-67.
  14. Chandler DJ, Fuller LC. A review of scabies: an infestation more than skin deep. Dermatology. 2019;235(2):79-90.
  15. Sanei-Dehkordi A, Soleimani-Ahmadi M, Zare M, Jaberhashemi SA. Risk factors associated with scabies infestation among primary schoolchildren in a low socio-economic area in southeast of Iran. BMC Pediatr. 2021;21(1):249.
  16. Gupta S, Thornley S, Morris A, Sundborn G, Grant C. Prevalence and determinants of scabies: a global systematic review and meta-analysis. Trop Med Int Health. 2024;29(12):1006-17.
  17. Haytoglu Z, Gundeslioglu OO, Karaman BF. Efficacy of combination therapy with oral ivermectin and topical permethrin versus permethrin monotherapy in pediatric patients with persistent scabies: a propensity score-adjusted observational study. BMC Infect Dis. 2025;25(1):1545.
  18. Bernigaud C, Fischer K, Chosidow O. The management of scabies in the 21st century: past, advances and potentials. Acta Derm Venereol. 2020;100(9):adv00112.
  19. Behera P, Munshi H, Kalkonde Y, Deshmukh M, Bang A. Control of scabies in a tribal community using mass screening and treatment with oral ivermectin: a cluster randomized controlled trial in Gadchiroli, India. PLoS Negl Trop Dis. 2021;15(4):e0009330.
  20. Engelman D, Marks M, Steer AC, Beshah A, Biswas G, Chosidow O, et al. A framework for scabies control. PLoS Negl Trop Dis. 2021;15(9):e0009661.