Journals / Turgut Özal Tıp Merkezi Dergisi / 2009 / Cilt: 16 Sayı: 2

Evaluation of the Epileptic Cases with Intracranial Space Occupying Lesion During Post Operative Period

İntrakranyal Yer Kaplayan Lezyonlu Epileptik Olgularda Postoperatif Değerlendirme

Pages
125–130
Publication Date
2009-04-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Key words: epilepsy, intracranial space occupying lesions, post operative status, anticonvulsant treatments

📌 3 Key Takeaways

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Objective & Hypothesis:Of the patients with cranial tumour 30 to 50% have generalised, partial or secondary generalisedseizures.
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Key Findings & Data:There were 6 patients ( 3 male) whom were operated for their intracranial space occupying lesions between 18-70 ages.
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Conclusion & Impact:Key words: epilepsy, intracranial space occupying lesions, post operative status, anticonvulsant treatments
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Epilepsi · İntrakranyal Yer Kaplayan Lezyonlar · Post Operatif Dönem

Abstract

Of the patients with cranial tumour 30 to 50% have generalised, partial or secondary generalisedseizures. Partial seizures let us to estimate the tumour localisation. In patients with space occupying lesion seizures may continue after the exicion of the tumour. We evaluatedthe post operative period of the patients who had intracranial tumuor. There were 6 patients ( 3 male) whom were operated for their intracranial space occupying lesions between 18-70 ages. All had epileptic seizures preoperatively exept one patient with hyphophysis adenoma.Of these, the duration with seizure onset between operation were minimum one month and maximum five years.Focal motor seizures, partial andsecondary generalised seizures were seen preoperatively. Post operative diagnoses were menengioma.2, astrositoma.1 oligodendroglioma1, glial tumour1 and hyphophysis adenoma1. Neurologic deficit were not seen any of the patients post operatively. The follow up period after operation were minimum 6 months and maximum 9 years. Four patients were operated for the second time who had the diagnosis of menengioma, astrositoma, oligodendroglioma,and hyphophysis adenoma. Seizure characteristics were changed and the seizure frequency were decreased of the patient who had glial tumourafter post operative period.Maximum seizure free period were 6 years. The menegioma patient had her seizures early in time in intensive care unit as focal motor seizures and no decrease were seen in seizure frequency during the post operative follow up.In parasagittal oligodendroglioma patient seizure frequency were increased post operatively. Four patients had poly therapy. Post operative seizure course is associated with the tumour localisation, size, pathologic diagnosis, and second or more operation.Of these patients it is conspicuousthat the seizure control is more difficult who were operated for the second or more times. Key words: epilepsy, intracranial space occupying lesions, post operative status, anticonvulsant treatments

Özet

Beyin tümörlü hastaların %30-50 sinde jeneralize, parsiyel veya parsiyel başlayıp jeneralize olannöbetlere rastlanır. Parsiyel nöbetler tümör yerinin belirlenmesinde yardımcıdır. Yer kaplayan lezyonu (YKL) olan hastalarda lezyonun eksizyonu sonrasında da nöbetler devam edebilir. Burada intrakranyal tümoral lezyonu olan hastaların operasyon sonrası izlemleri değerlendirilmiştir Yaşları 18-70 arasında değişen intrakranyal yer kaplayan lezyon nedeni ile opere olan 3'ü erkek toplam 6 hasta mevcuttu. Bunlardan hipofiz adenomu tanısı alan 1 erkek hasta dışında hepsinin preoperatif dönemde epileptik nöbet öyküsü vardı. Diğer 5 hastada nöbet başlangıcı ve operasyon arası süre 1 ay ila 5 yıl idi. Preoperatif nöbet özellikleri fokal motor nöbet, kötü koku ile karakterize basit parsiyel nöbet ve sekonder jeneralize nöbetler şeklinde idi. Post operatif tanı 2 hastada menengiom, 1 astrositom, 1 oligodendrogliom, 1glial tm ve 1 hipofiz adenomu idi. Post operatif dönemde hiçbir hasta da nörolojik defisit oluşmadı. Post operatif izlem süresi 6 ay ila 9 yıl idi. Astrositom, Oligodendrogliom, Menengiom ve Hipofiz adenomu tanısı alan 4 hasta 1 ila 4 yıl arayla ikinci kez opere edilmişti.Glial tümör tanısı alan 50 yaşındaki bayan hastada post operatif dönemde nöbetler azalmakla beraber karakteristiği değişti. Post operatif en uzun nöbetsizlik süresi 6 yıl idi. Post operatif en erken nöbet, menengioma tanısı alan 1 hastada, yoğun bakımda fokal motor nöbet şeklinde idi. Bu hastanın pre ve post operatif dönemde nöbet sıklığında değişiklik olmadı. Parasagittal oligodendrogliom nedeni ile opere olan 18 yaşındaki bayan hasta da post operatif dönemde nöbet sıklığında artış gözlendi. 2 hastada antiepileptik tedavimonoterapi, 4 hastada politerapi şeklinde devam ediyordu. İntrakranyal tümoral lezyonu olan epileptik hastalarda post operatif nöbet seyri lezyonun yeri, büyüklüğü, patolojik tanısı, geçirilen operasyon ile ilişkilidir. Bu hastalardan ikinci kez opere olanların nöbet kontrolünün daha güç olduğu dikkat çekicidir. Anahtar kelimeler: Epilepsi, İntrakranyal Yer Kaplayan Lezyonlar, Post Operatif Dönem, Antikonvülzan Tedavi

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Cite This Article

KABAY, S. C., KARAMAN, H. Ö., ERDİNÇ, O., DURMAZ, R. (2009). Evaluation of the Epileptic Cases with Intracranial Space Occupying Lesion During Post Operative Period. Turgut Özal Tıp Merkezi Dergisi, Cilt: 16 Sayı: 2, 125–130. https://ajindex.com/articles/1010004

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References (11)

  1. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia 1993; 34: 453–68.
  2. Glantz MJ, Cole BF, Forsyth PA, et al. Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000; 54: 1886–93. Taphoorn MJ. Neurocognitive sequelae in the treatment of lowgradegliomas. Semin Oncol 2003; 30: 45–8. Herman ST. Epilepsy after brain insult: targeting epileptogenesis. Neurology 2002; 59 (suppl 5): 21–6.
  3. Wen PY, Marks PW. Medical management of patients with brain tumors. Curr Opin Oncol 2002; 14: 299–307.
  4. Van Veelen ML, Avezaat CJ, Kros JM, van Putten W, Vecht C. Supratentorial low grade astrocytoma: prognostic factors, dedifferentiation, and the issue of early versus late surgery. J Neurol Neurosurg Psychiatry 1998; 64: 581–7. Cascino GD. Epilepsy and brain tumors: implications for treatment. Epilepsia 1990; 31 Pasquier B, Peoc’H M, Fabre-Bocquentin B, et al. Surgical (suppl 3): 37–44. pathology of drug-resistant partial epilepsy. A 10-year-experience with a series of 327 consecutive resections. Epileptic Disord 2002; 4: 99–119.
  5. Moots PL, Maciunas RJ, Eisert DR, Parker RA, Laporte K, Abou-Khalil B. The course of seizure disorders in patients with malignant gliomas. Arch Neurol 1995; 52: 717–24.
  6. Chang EF, Potts MB, Keles GE, Lamborn KR, Chang SM, Barbaro NM, Berger MS Seizure characteristics and control following resection in 332 patients with low-grade gliomas. J Neurosurg. 2008 Feb;108(2):227-35.
  7. Lieu AS, Howng SL. Intracranial meningiomas and epilepsy: incidence, prognosis and influencing factors. Epilepsy Res 2000; 38: 45–52.
  8. Sirven JI, Wingerchuk DM, Drazkowski JF, Lyons MK, Zimmerman RS. Seizure prophylaxis in patients with brain tumors: a metaanalysis.Mayo Clin Proc 2004; 79: 1489–94. Schaller B. Infl uences of brain tumor-associated pH changes and hypoxia on epileptogenesis. Acta Neurol Scand 2005; 111: 75–83.
  9. Beaumont A, Whittle IR. The pathogenesis of tumour associated epilepsy. Acta Neurochir (Wien) 2000; 142: 1–15.
  10. Aronica E, Yankaya B, Jansen GH, et al. Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy. Neuropathol Appl Neurobiol 2001; 27: 223–37.
  11. Morrell F, Toledo-Morrell L. From mirror focus to secondary epileptogenesis in man: an historical review. Adv Neurol 1999; 81: 11–23. M