SavedAdd your journal

Journals / Medical Science and Discovery / 2016 / Cilt: 3 Sayı: 4

Plasma adrenomedullin levels in patients with migraine during natural attack and attack free period

Medical Science and Discovery

Aylin Akcali
Sirma Geyik
Ilker Dogru
Arzu Dogru
Muhittin Yurekli
Abdurrahman Neyal
Ayse Balat
Munife Neyal
Pages
153–8
Publication Date
2016-04-15
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies regarding on AM involvement in migraine pathophysiology are needed to confirm these results.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The role of Calcitonin G related peptide (CGRP) in migraine has been demonsrated.
📊
Key Findings & Data:The aim of this study was to examine the role of Adrenomedullin (AM) which is a member of the calcitonin/CGRP/amylin family in migraine patients during naturel attack and attack free period.Material and Methods: 26 migraine patients (11 with aura, 15 without aura) and 26 healty participants were involved.
💡
Conclusion & Impact:Further studies regarding on AM involvement in migraine pathophysiology are needed to confirm these results.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Adrenomedullin · Calcitonin · CGRP

Abstract

Objective: The role of Calcitonin G related peptide (CGRP) in migraine has been demonsrated. The aim of this study was to examine the role of Adrenomedullin (AM) which is a member of the calcitonin/CGRP/amylin family in migraine patients during naturel attack and attack free period.Material and Methods: 26 migraine patients (11 with aura, 15 without aura) and 26 healty participants were involved. Blood samples were obtained from each patient in attack and attack free period, then compared with each other and control group.Results: Mean plasma AM levels were 18.95 pmol/L during migraine attacks, 26.01 pmol/L between attacks, and 33.38 pmol/L in the control group. AM levels of migraine patients were significantly lower than controls during non-attack periods (p=0.001) and more interestingly, it further decreased during attack periods (p=0.001). A comparison of the mean plasma AM levels of migraine with and without aura cases revealed the same statistically significant difference (p=0.00).Conclusion: The persistently low AM levels in migraine patients gave the impression that in physiological conditions there may be a balance between CGRP and AM and this may be changed towards to the site of CGRP in migraine pathophysiology while causing a decline in AM levels as we had found. Further studies regarding on AM involvement in migraine pathophysiology are needed to confirm these results.

🔖

Cite This Article

Akcali, A., Geyik, S., Dogru, I., Dogru, A., Yurekli, M., Neyal, A., Balat, A., Neyal, M. (2016). Plasma adrenomedullin levels in patients with migraine during natural attack and attack free period. Medical Science and Discovery, Cilt: 3 Sayı: 4, 153–8. https://ajindex.com/articles/1003082

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 1990, 28(2):183-87.
  2. Kis B, Abraham CS, Deli MA, Kobayashi H, Wada A, Niwa M, Yamashita H, Ueta Y. Adrenomedullin in the cerebral circulation. Peptides 2001, 22(11):1825-1834.
  3. Lassen LH, Haderslev PA, Jacobsen VB, Iversen HK, Sperling B, Olesen J. CGRP may play a causative role in migraine. Cephalalgia 2002, 22(1):54-61.
  4. Walker CS, Hay DL. CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors? Br J Pharmacol, 170(7):1293-307.
  5. Kruuse C, Frandsen E, Schifter S, Thomsen L L, Birk S, Olesen J. Plasma levels of cAMP, cGMP and CGRP in sildenafil-induced headache. Cephalalgia, 2004. 24(7): 547-53.
  6. Petersen KA, Birk S, Kitamura K, Olesen J. Effect of adrenomedullin on the cerebral circulation: relevance to primary headache disorders. Cephalalgia 2009, 29(1):23-30.
  7. Friberg L, Olesen J, Olsen TS, Karle A, Ekman R, Fahrenkrug J. Absence of vasoactive peptide release from brain to cerebral circulation during onset of migraine with aura. Cephalalgia 1994, 14(1):47-54.
  8. Tfelt-Hansen P, Le H. Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. J Headache Pain 2009, 10(3):137-43.
  9. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993, 192(2):553-60.
  10. Kis B, Deli MA, Kobayashi H, Abraham CS, Yanagita T, Kaiya H, Isse T, Nishi R, Gotoh S, Kangawa K et al. Adrenomedullin regulates blood-brain barrier functions in vitro. Neuroreport 2001, 12(18):4139-42.
  11. Kis B, Kaiya H, Nishi R, Deli MA, Abraham CS, Yanagita T, Isse T, Gotoh S, Kobayashi H, Wada A et al. Cerebral endothelial cells are a major source of adrenomedullin. J Neuroendocrinol 2002, 14(4):283-93.
  12. Bela K, Csongor AS, Deli MA, Ueta Y. Adrenomedullin and migraine. Headache 2002, 42(10):1064-65.
  13. Kis B, Abraham CS, Deli MA, Kobayashi H, Niwa M, Yamashita H, Busija DW, Ueta Y. Adrenomedullin, an autocrine mediator of blood-brain barrier function. Hypertens Res 2003, 26 Suppl:S61-70. Petersen KA, Birk S, Kitamura K, Olesen J. Effect of adrenomedullin on the cerebral circulation: relevance to primary headache disorders. Cephalalgia 2009, 29(1):23-30. The International Classification of Headache Disorders. 2nd edition. Cephalalgia 2004, 24 Su