SavedAdd your journal

Journals / Journal of Clinical and Experimental Investigations / 2011 / Cilt: 2 Sayı: 2

Association of a single nucleotide polymorphism in the SUR1 gene with type 2 diabetes and obesity in Turkish patients

Türk Toplumunda Tip 2 Diyabet'in ve Obezitenin, SUR1 genindeki tek nükleotit polimorfizmi ile birlikteliği

Osman Evliyaoglu
Enver Sancaktar
Erkan Söğüt
Mustafa Kemal Başaralı
Nuriye Uzuncan
Baysal Karaca
Pages
161–167
Publication Date
2011-06-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: A significant increase in the frequency of the A allele was observed in type 2 diabetic patients compared with that of the control group (41% vs. 24%, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Sulfonylurea receptor 1 (SUR1) gene codes the SUR1 protein that plays a key role in glucose-induced in-sulin secretion.
📊
Key Findings & Data:In this study, we have investigated the relationship between the polymorphism in exon 31 of the SUR1 gene and type 2 diabetes, and its association with obesity in Turkish diabetic patients.
💡
Conclusion & Impact:Results: A significant increase in the frequency of the A allele was observed in type 2 diabetic patients compared with that of the control group (41% vs. 24%, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tip 2 diyabet · obezite · SUR1 gen polimorfizmi

Abstract

Objectives: Sulfonylurea receptor 1 (SUR1) gene codes the SUR1 protein that plays a key role in glucose-induced in-sulin secretion. In this study, we have investigated the relationship between the polymorphism in exon 31 of the SUR1 gene and type 2 diabetes, and its association with obesity in Turkish diabetic patients. Materials and methods: A total of 90 patients (45 males and 45 females, aged 43-70 years old) who were followed up in the diabetes outpatient clinic were enrolled in the study. Serum glucose, triglyceride, cholesterol and blood HbA1c levels were determined. The SNPs in exon 31 were examined by a polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) method. Results: A significant increase in the frequency of the A allele was observed in type 2 diabetic patients compared with that of the control group (41% vs. 24%, p

Özet

Amaç: Sulfonylurea receptor 1 (SUR1) geni SUR1 proteinini kodlayarak glukozla indüklenen insülin sekresyonunda anahtar rolü oynar. Bu çalışmanın amacı, SUR1 geninin 31. ekzonundaki polimorfizm ile Tip 2 diyabet arasındaki ilişkiyi ve diyabetik hastalardaki obezite ile beraberliğini araştırmaktır. Gereç ve yöntem: Diyabet polikliniğinde takip edilen 90 hasta (45 kadın, 45 erkek ) çalışmaya dahil edildi. Serumda glukoz, trigliserid, kolesterol ve tam kanda HbA1c değerleri belirlendi. 31. Egzondaki SNP'ler ise polymeraz zincir reak-siyon / restriksiyon fragment uzunluk polymorphism (PCR-RFLP) yöntemiyle belirlendi. Bulgular: Kontrol grubu ile karşılaştırıldığında Tip 2 diyabetik hastalarda A allel frekansının artmış olduğu gözlendi (%41 ve %24, p

🔖

Cite This Article

Evliyaoglu, O., Sancaktar, E., Söğüt, E., Başaralı, M. K., Uzuncan, N., Karaca, B. (2011). Association of a single nucleotide polymorphism in the SUR1 gene with type 2 diabetes and obesity in Turkish patients. Journal of Clinical and Experimental Investigations, Cilt: 2 Sayı: 2, 161–167. https://ajindex.com/articles/1001286

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. American Diabetes Association. Report of the expert com- mittee on the diagnosis and classification of diabetes mel- litus. Diabetes Care 1997; 20(7): 1183-97.
  2. Ashcroft FM, Gribble FM. ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabeto- logia 1999; 42(8): 903-19.
  3. Inagaki N, Gonoi T, Clement JP, et al. Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 1995; 270(5239): 1166-70.
  4. Aguilar-Bryan L, Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocrine Rev 1999; 20(2): 101-35.
  5. Thomas PM, Wohllk N, Huang E, et al. Inactivation of the first nucleotide-binding fold of the sulfonylurea receptor, and familial persistent hyperinsulinemic hypoglycemia of infancy. Am J Hum Genet 1996; 59(3): 510-18. DeFronzo RA. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Reviews 1997; 5(3): 177-85.
  6. Velho G, Froguel P. Genetic determinants of non-insulin- dependent diabetes mellitus: strategies and recent results. Diabetes Metab 1997; 23(1): 7-17.
  7. Hani EH, Clément K, Velho G, et al. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians. Diabetes 1997; 46(4): 688-94.
  8. Hansen T, Echwald SM, Hansen L, et al. Decreased tolbut- amide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene. Diabetes 1998; 47(4): 598-605. Hart LM, de Knijff P, Dekker JM, et al. Variants in the sul- phonylurea receptor gene: association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians. Diabetologia 1999; 42(5): 617-20.
  9. Goksel DL, Fischbach K, Duggirala R, et al. Variant in sul- fonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia. Hum Genet 1998; 103(3): 280-5.
  10. Reis AF, Ye WZ, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G. Association of a variant in exon 31 of the sulfonylurea receptor 1 (SUR1) gene with type 2 diabetes mellitus in French Caucasians. Hum Genet 2000; 107(2): 138-44.
  11. Thomas PM, Cote GJ, Hallman DM, Mathew PM. Ho- mozygosity mapping, to chromosome 11p, of the gene for familial persistent hyperinsulinemic hypoglycemia of in- fancy. Am J Hum Genet 1995; 56(2): 416-21.
  12. Hamming KS, Soliman D, Matemisz LC, et al. Coexpres- sion of the type 2 diabetes susceptibility