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Journals / Journal of Clinical and Experimental Investigations / 2016 / Cilt: 7 Sayı: 1

The Effect of Elevated Homocysteine Levels on Atherosclerosis in Patients with Peritoneal Dialysis

Fatih ŞAHPAZ
Pages
47–51
Publication Date
2016-03-01
DOI
—
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J Clin Exp Invest 2016; 7 (1): 47-51

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Cardiovascular disease is an important cause of morbidity and mortality in patients with renal failure.
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Key Findings & Data:Patients with chronic renal failure are significantly susceptible to atherosclerosis.
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Conclusion & Impact:J Clin Exp Invest 2016; 7 (1): 47-51
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:İnflamasyon · homosistein · intima media kalınlığı

Abstract

Objective: Cardiovascular disease is an important cause of morbidity and mortality in patients with renal failure. Patients with chronic renal failure are significantly susceptible to atherosclerosis. In the present study, we aimed to investigate the effect of elevated homocysteine on atherosclerosis and inflammation in continuos ambulatory peritoneal dialysis (CAPD) patients. Methods: 56 patients undergoing CAPD and 27 healthy subjects was enrolled in the study. All patients total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, hs-CRP, homocysteine, intima-media thickness, arterial stiffness values were measured and statistically analyzed. Results: It is determined that the levels of total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, homocysteine, intima-media thickness, arterial stiffness and hs-CRP was higher in patients compared to the control group (in order; p=0.03, p=0.0006, p=0.02). Conclusion: Carotid intima-media thickness being increased because of increased levels of homocysteine and inflammation in CAPD patients. Therefore, in case of atherosclerosis, hyperlipidemia and inflammation more aggressive treatment protocol should be considered. Patients with elevated plasma homocysteine concentrations should be treated. J Clin Exp Invest 2016; 7 (1): 47-51

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Cite This Article

ŞAHPAZ, F. (2016). The Effect of Elevated Homocysteine Levels on Atherosclerosis in Patients with Peritoneal Dialysis. Journal of Clinical and Experimental Investigations, Cilt: 7 Sayı: 1, 47–51. https://ajindex.com/articles/1001211

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