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Journals / Journal of Clinical and Experimental Investigations / 2016 / Cilt: 7 Sayı: 3

The Association Between MGP Gene Polymorphisms and Coronary Artery Disease

Mehmet Zihni BİLİK
Ali Fuad KARA
Bülent GÖĞEBAKAN
Mehmet Ata AKIL
Ferhat ÖZYURTLU
Halit ACET
Sait ALAN
Pages
229–236
Publication Date
2016-09-02
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, according to our findings, there was no statistically significant difference between the CAD and the control group.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Coronary artery calcification (CAC) is associated with coronary atherosclerosis.
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Key Findings & Data:There is a significant relation between coronary artery wall calcification and coronary artery disease (CAD).
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Conclusion & Impact:However, according to our findings, there was no statistically significant difference between the CAD and the control group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Coronary artery disease · vascular calcification · matrix Gla Protein

Abstract

Objectives: Coronary artery calcification (CAC) is associated with coronary atherosclerosis. There is a significant relation between coronary artery wall calcification and coronary artery disease (CAD). The measure of coronary artery calcification is an indicator of subclinical atherosclerosis. In some studies, it has been shown that coronary artery calcification is independent from conventional cardiovascular risks, which suggests data about prognosis. Matrix Gla protein (MGP) is an important protective modulator against calcification since it is an inhibitor of tissue calcification. In this respect, we aimed to establish the relationship between the distributions of nucleotide alterations found in promoter and coding regions of the MGP gene in patients with CAD and patients with normal coronary. Methods: DNA samples (n=115) were obtained from 58 patients with CAD and 57 healthy controls. The DNA samples obtained were analyzed by a Polymerase Chain Reaction (PCR) method using three sets of primer pairs, which cover the coding (Thr83Ala in exon 4) and promoter regions (T-138C and G-7A) of the MGP gene. Amplified regions were analyzed by a Restriction Fragment Length Polymorphism (RFLP) method for possible polymorphisms. Results: The chi-square analysis of the results revealed that there is no relationship between the observed polymorphisms and CAD. Conclusions: In this study, we investigated the relationship between MGP gene polymorphism and CAD. However, according to our findings, there was no statistically significant difference between the CAD and the control group.

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Cite This Article

BİLİK, M. Z., KARA, A. F., GÖĞEBAKAN, B., AKIL, M. A., ÖZYURTLU, F., ACET, H., ALAN, S. (2016). The Association Between MGP Gene Polymorphisms and Coronary Artery Disease. Journal of Clinical and Experimental Investigations, Cilt: 7 Sayı: 3, 229–236. https://ajindex.com/articles/1001181

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