 Determination of lethal doses of volatile and fixed oils of several plants

Abstract

Objective: To determine lethal doses of fixed and/orvolatile oils extracted from leafs or fruits of Pimpinellaanisum, Foeniculum vulgare, Sesamum indicum,Eugenia caryophyllata, Nigella sativa, Urtica pilulifera,Apium graveolens, Cuminum cyminum, Coriandrumsativum and Thymus fallax.Method: Swiss albino mice were injectedintraperitoneally with different concentrations of theextract and results were evaluated with the method ofprobit analysis.Results: Maximum volume of oil administered to micewas kept below 0.5 ml. The oils of Sesamum indicumand Urtica pilulifera was completely non-lethal even atdoses reaching 12.8 ml/kg and considered non-toxic.Conclusion: Lethal doses were determined for all otherplants and LD1, LD10, LD50, LD90 and LD99 values weregiven.Key words: Volatile oil, fixed oil, lethal doses, plants