Dergiler / Pharmata / 2023 / Cilt: 3 Sayı: 4
The Role of Myocardial Performance Index in Evaluating Effect of Hypothyroidism on Systolic and Diastolic Functions of Heart
- Dergi
- Pharmata
- Sayfa
- 87–90
- DOI
- —
Özet
Objective: Hypothyroidism causes pathological changes in the heart. Systolic and diastolic functions of the left ventricle of the heart can be evaluated with the myocardial performance index (MPI). We compared MPI in overt hypothyroidism patients vs. healthy group. Methods: The study included 50 healthy control subjects and 50 overt hypothyroid patients. Echocardiographic procedure was performed in all patients. The following parameters, like ejection fraction (EF), diastolic transmitral peak velocity (E and A waves), E/A ratio, and MPI, were measured. Results: The E wave (0.79 ± 0.26 m/s) and E/A ratio (0.95 ± 0.30), which are echocardiographic parameters that reflect cardiac diastolic dysfunction, were dramatically lower in the case group (P < .05). Myocardial performance index (MPI) (0.42 ± 0.04), which reflects systolic and diastolic functions of the heart, was significantly higher in the case group (P < .05). Ejection fraction value (62.5 ± 4.0%) was not statistically different between the case and healthy subjects (P > .05). Conclusion: Significant decrease in E and E/A values in the hypothyroid patients indicated the development of diastolic dysfunction. Although no difference could be detected between the groups in EF value, which reflects systolic functions of the heart, a significant increase in MPI value in the hypothyroid group indicated that systolic and diastolic functions of the heart started to deteriorate. In our study, the elevation of the MPI in hypothyroid patients without EF impairment suggests that MPI should be practiced more widely in the evaluation of cardiac functions in hypothyroid patients.
Abstract
Objective: Hypothyroidism causes pathological changes in the heart. Systolic and diastolic functions of the left ventricle of the heart can be evaluated with the myocardial performance index (MPI). We compared MPI in overt hypothyroidism patients vs. healthy group. Methods: The study included 50 healthy control subjects and 50 overt hypothyroid patients. Echocardiographic procedure was performed in all patients. The following parameters, like ejection fraction (EF), diastolic transmitral peak velocity (E and A waves), E/A ratio, and MPI, were measured. Results: The E wave (0.79 ± 0.26 m/s) and E/A ratio (0.95 ± 0.30), which are echocardiographic parameters that reflect cardiac diastolic dysfunction, were dramatically lower in the case group (P < .05). Myocardial performance index (MPI) (0.42 ± 0.04), which reflects systolic and diastolic functions of the heart, was significantly higher in the case group (P < .05). Ejection fraction value (62.5 ± 4.0%) was not statistically different between the case and healthy subjects (P > .05). Conclusion: Significant decrease in E and E/A values in the hypothyroid patients indicated the development of diastolic dysfunction. Although no difference could be detected between the groups in EF value, which reflects systolic functions of the heart, a significant increase in MPI value in the hypothyroid group indicated that systolic and diastolic functions of the heart started to deteriorate. In our study, the elevation of the MPI in hypothyroid patients without EF impairment suggests that MPI should be practiced more widely in the evaluation of cardiac functions in hypothyroid patients.