The Role of p-Coumaric Acid on Reproductive and Remote Organ Damages Created by Adnexal Torsion/Detorsion: Biochemical and Immunohistochemical A Study

Abstract

Objective: We planned to search the effects of p-coumaric acid on ovary and lung injuries formed via bilateral adnexal torsion detorsion (T/D) in experimental rat model. Methods: 24 female, Sprague-Dawley rats were sorted out as 3 groups. Design of the groups was performed as sham (group I) and T/D (group II), p-coumaric acid+T/D (group III) groups. Sham group; abdomen area was applied incision and repaired with no T/D model application. T/D group; 3 h of torsion phase completed and then 3 h of detorsion stage was established. P-coumaric acid+T/D group; p-coumaric acid was administered at the dose of 100 mg/kg for 15 days by oral gavage and then, T/D model was performed. Following detorsion phase, rats were sacrificed, lung and ovarian tissues were excised for biochemical and immunohistochemical evaluations. Results: When it is compared to group I, oxidant parameters elevated significantly in group II (p