Monocyte to HDL Ratio in Preeclamptic Patients: Can It Be a Predictive Marker?

Abstract

Objective: Preeclampsia (PE) is a severe and high – risk pregnancy complication for both the mother and fetus. Generalized inflammation is a prominent feature of PE. Based on the proinflammatory property of monocytes and the contrary anti-inflammatory mechanism of High-density lipoprotein (HDL), monocyte count to HDL ratio (MHR) could be used as a new marker of systemic inflammation. Our aim is to evaluate the relationship between PE and MHR in terms of diagnosis of PE. Methods: A retrospective case-control study was recruited preeclamptic and healthy pregnant women in the third trimester of gestation (n=69 and n= 71, respectively). Results: Maternal age (years), gravity, and body mass index (BMI) were similar in the two groups. The gestational week at delivery was significantly earlier in the PE group than in the control group (p