High GAL-3 may be Associated with Higher Age and Low Levels of Chloride, RDW, and MCHC in Heart Failure

Abstract

Introduction: Elevated galectin-3 GAL-3 levels has been associated with decompensated heart failure HF which is a complex mechanical and neurohormonal syndrome. Many clinical and biochemical factors have been implicated in the pathophysiology of HF. In a group of patients who are referred to the emergency clinic for HF, GAL-3 levels and their association with various clinical and biochemical parameters were determined. GAL-3levels were measured with the VIDAS® automated enzyme-linked fluorescent assay BioMérieux, France . Method: Our study group consists of 70 patients 33 women and 37 men and 25 healthy controls. All 70 patients had at least Class II or higher levels of HF according to NYHA criteria. Results: GAL-3 was significantly higher in the patient's group 17.98 vs. 10.24 ng/mL; p