ANALGESIC NEPHROPATHY

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs), which are easily accessible, inexpensive and have many therapeutic effects, are used frequently and in large quantities by every age group of patients. NSAIDs reversibly inhibit cyclooxygenase enzymes at various degrees and they have the same action and toxicity mechanism. These groups of drugs can cause damage in many organs when there used at high dose and for a long-time period. Analgesic nephropathy is one of the prominent side effects of NSAIDs which damage kidneys. The present review focused on renal toxic mechanisms induced by NSAIDs. The geriatric group which is the most vulnerable group to misusage of NSAIDs should be well informed and monitored by healthcare professionals to decrease the risk of adverse effects related to NSAIDs.