Investigation of the contribution of concentrated growth factor (CGF) and processed lipoaspirate (PLA) to wound healing in diabetic rats

Abstract

ABSTRACT Aim: The aim of the study is to show the effectiveness of concentrated growth factor (CGF) and processed lipoaspirate (PLA) in wound healing in diabetic rats. Materyal and Method: A total of 30 rats were used in the study. İt was divided into 3 groups as CGF, PLA and control group. The rats were made diabetic using Sreptozotocin IP. A 5mm diameter wound was created on one of the hind legs of all rats by using a punch. CGF and PLA were applied to the lesions. Daily wound size and wound condition were recorded on days 3, 5 and 10. At the end of the study, blood samples were taken for TNF-α, TGF-β, IL-1, PDGF, FGF and VEGF measurements before the rats were sacrificed. Results: The mean wound diameters measured on the 3rd day in the study were 4.6 ± 0.06 mm in the control group, 4.1 ± 0.05 mm in the CGF group, and 4.4 ± 0.07 mm in the PLA group. The wound diameters measured on the 5th day were 3.1 ± 0.04 mm in the control group, 1.6 ± 0.05 mm in the CGF group and 2.7 ± 0.06 mm in the PLA group (P 0.05). Conclusion: In this study, it was shown that CGF application was more effective than PLA application in wound healing in diabetic rats. Keywords: CGF, PLA, diabetic rat, ulcer