Dergiler / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2018 / Cilt: 38 - Sayı: 1

Evaluation of Antimicrobial Activity of Three Endemic Salvia Species Growing in Turkey

Evaluation of Antimicrobial Activity of Three Endemic Salvia Species Growing in Turkey

Sevda GÜZEL, Yusuf ÖZAY, Mahmut ÜLGER, Ahmet KAHRAMAN, Gönül ASLAN

Sayfa
4–10
DOI
—

Abstract

The ethanol extracts obtained from the aerial parts of three Salvia species (S. hypargeia,S. huberi and S. dichroantha) which are endemic to Turkey were tested for their antibacterialand antifungal activities against two Gram (+) bacterial strains [Staphylococcusaureus (ATCC 25925), Bacillus subtilis (ATCC 6633)]; three Gram (-) bacterial strains[Escherichia coli (ATCC 25923), Acinetobacter baumannii (ATCC 02026), Aeromonashydrophila (ATCC 95080)] and Mycobacterium tuberculosis H37Rv, and three fungalstrains (Candida glabrata ATCC 90030, C. parapsilosis ATCC 22019, C. tropicalisATCC 750) by using the broth microdilution method. All tested plant extracts showedsignificantly antibacterial activity against A. baumannii (ATCC 02026) (62.5 μg/mLMIC value) when compared to reference drug Ampicillin (125 μg/mL MIC value).The ethanolic extract of S. huberi was found the most effectiveness extract against M.tuberculosis H37Rv with 0.97 μg/mL MIC value when compared to reference antimycobacterialagents Isoniazid and Ethambutol (0.97 μg/mL and 1.95 μg/mL MIC values,respectively).