Dergiler / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2021 / Cilt: 41 - Sayı: 2
Creatine and α-lipoic acid improved behavioral parameters of depression induced by dexamethasone in mice
- Sayfa
- 65–73
- DOI
- —
Özet
Objective: Corticosterone treatment in mice impairs mitochondrial function, decreases energy production in the brain, and induces depressive-like behaviors. Creatine (Crt) is vital for energy homeostasis in the brain. Alpha-lipoic acid (ALA) improves mitochondrial function and reduces oxidative stress. The aim was investigating the effect of Crt and ALA following dexamethasone (Dexa) induced depression in mice model of despair. Methods: Female mice (22±3 g) were experimented. Dexa (15 mcg/kg, SC) injected for a week, Crt was inserted in animals’ diet, and ALA (25, 50 mg/kg) injected IP. After the locomotor test, behavioral parameters of depression, including immobility time during the forced swimming test (FST), and anhedonia during the sucrose preference test were evaluated. Results: There was not important changes during the locomotor test. Dexa increased the immobility time during the FST (154 ± 6.3 s vs control 119±5.5 s, p
Abstract
Objective: Corticosterone treatment in mice impairs mitochondrial function, decreases energy production in the brain, and induces depressive-like behaviors. Creatine (Crt) is vital for energy homeostasis in the brain. Alpha-lipoic acid (ALA) improves mitochondrial function and reduces oxidative stress. The aim was investigating the effect of Crt and ALA following dexamethasone (Dexa) induced depression in mice model of despair. Methods: Female mice (22±3 g) were experimented. Dexa (15 mcg/kg, SC) injected for a week, Crt was inserted in animals’ diet, and ALA (25, 50 mg/kg) injected IP. After the locomotor test, behavioral parameters of depression, including immobility time during the forced swimming test (FST), and anhedonia during the sucrose preference test were evaluated. Results: There was not important changes during the locomotor test. Dexa increased the immobility time during the FST (154 ± 6.3 s vs control 119±5.5 s, p