What did change in poor ovarian responders according to Bologna criteria over the 5 years? A tertiary IVF center experience

Abstract

Objective: The objective of the study was to evaluate the changes in the prevalence, management strategies, and cycle outcomes of the cycle with the poor ovarian re- sponse (POR). Material and Methods: This study was retrospectively designed. Poor responder in- fertile women who fulfilled Bologna criteria were included in the study. Data were ob- tained from medical records of infertile couples who underwent the intracytoplasmic sperm injection and embryo transfer program from January 2014 to December 2018. Results: Totally 776 cycles with POR were evaluated. The changing trend in the prev- alence of the cycle with POR was estimated by rejecting the null hypothesis that there is no linear trend in the proportion of poor cycles across years (χ2(1)=9.28, p=0.002). A linear increasing trend in the proportion of poor cycles in the 5 years was found. A linear increase in the prefer of the antagonist protocol was found (χ2(1)=6.61, p=0.010), whereas there was a linear decrease in the minimal stimulation protocol with Clomiphene Citrate (χ2(1)=11.028, p