Prognostic Value of Systemic Immune-Inflammation Index in Patients with Testicular Cancer: A Retrospective Case- Control Study

Abstract

Objective: The primary aim of this study was to evaluate the correlation between the systemic immune-inflammation index (SII) and clinicopathological outcomes of patients with testicular cancer (TCa). The secondary aim was to evaluate the relation of SII with overall survival (OS). Materials and Methods: A total of 244 patients were included in the study. Patients were divided into the testicular tumor (group 1, n=184) and control group (group 2, n=60). Preoperative complete blood count, tumor markers, and imaging tests of the patients in group 1 were recorded. A subgroup analysis was performed according to the clinical stage, pathological stage, tumor type, and tumor size. Then, the effectiveness of TCa on SII was evaluated among the groups. Results: A significant difference was observed between the SII, neutrophil, and neutrophil-to-lymphocyte ratios between groups 1 and 2. The median SII was 719.92 in group 1 and 510.93 in group 2 (p