Thiol-disulphide homeostasis in chronic sinusitis without polyposis

Abstract

Objectives: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed toinvestigate a novel oxidative stress marker, thiol/disulphide homeostasis.Patients and Methods: A total of 60 subjects (30 chronic sinusitis patients and 30 healthy volunteers) were included in the study.Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu.Results: The average native thiol value of the chronic sinusitis group was 475.6 µmol/L and 515.8 µmol/L in the control group.The total thiol was 509.4 and 552.2 µmol/L respectively for the chronic sinusitis and control groups. Chronic sinusitis patients hadsignificantly lower native and thiol value than control group (p