Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer

Abstract

Objective. Inflammation and oxidative stress are considered as the main pathways in oral cavity carcinoma.The aim of this study was to evaluate the activity levels of adenosine deaminase (ADA), nitric oxide (NO),nitric oxide synthase (NOS), and xanthine oxidase (XO) in oral cavity carcinoma, to determine their potentialroles in carcinogenesis with relation to oxidative stress. Methods. Seventeen patients with oral cavity cancerunderwent surgery as the primary therapy, were consisted in the study. Resected oral cavity carcinoma tissueswere compared with the adjacent tumor-free control tissues of the same patients; ADA, NO, NOS, XO activitylevels were evaluated in terms of difference. Results. There is a significant increase of ADA activity insquamous cell cancer tissues, which indicates a difference between the normal and tumor tissues at enzymelevels (p