Red cell distribution width and red cell distribution width to total serum calcium ratio as predictors of mortality in acute pancreatitis: a retrospective cohort study

Abstract

Objectives: We investigated whether red cell distribution width (RDW) and red cell distribution width to totalserum calcium (RDW-to-TSC) ratio were associated with mortality in patients with acute pancreatitis (AP).Methods: A total of 170 patients who present emergency department between January 2017 and June 2018with a diagnosis of AP were enrolled in this study. A comparison between survivor and nonsurvivor AP patientswas performed. Diagnosis of AP were defined according to the revised Atlanta classification 2012. Variablesevaluated included demographics, hospital stay, laboratorial parameters and mortality.Results: AP related in-hospital mortality was 6.4%. Red cell distribution (RDW), white blood cell (WBC),platelet, serum glucose and RDW-to-TSC ratio were associated with AP mortality. RDW-to-TSC ratio had thehighest AUC (0.88; 95% CI, 0.756-1.0), followed by RDW, serum glucose, platelet and WBC (AUC = 0.801,0.797, 0.743 and 0.687 respectively). A cut-off value of RDW-to-TSC ratio >2.0, the highest sensitivity (91.9%),specificity (81.1%), PPV (82.9%), and NPV (91.1%) were achieved for prediction of AP related in-hospitalmortality in approximately 86.5% of the cases (p 16.6 and RDW-to-TSC > 2.0 were verygood predictors for AP mortality.