Evaluation of plasma catestatin levels in patient with coronary slow flow

Abstract

Objectives: Coronary slow flow (CSF) is characterized by delayed opasification of the coronary arteries inthe absence of obstructive coronary disease. Catestatin has several cardiovasculer actions, in addition todiminihed sympato-adrenal flow. The study was to investigated associations between CSF and plasma catestatinlevels.Methods: This study included 45 CSF patients (37 males, mean age 48 ± 9.5 years) and 30 control individuals(24 males, mean age 48.4 ± 9 years). Coronary flow was quantified according to the TIMI (Thrombolysis inMyocardial Infarction) frame count method for coronary arteries. Serum catestatin levels taken from bloodsamples were measured by ELISA method. These parameters were compared between the groups.Results: When compared with to the control group the serum catestatin levels was found higher in the CSFgroup. In addition to this, mean platelet volume was also significantly higher in patients with coronary slowflow.Conclusions: Our study revealed that catestatin levels are increased in patients with CSF. Coronary slow flowthat increased catecholaminergic sympathetic system activities seem to be among the reasons of endothelialdysfunction.