Comparison of laboratory and imaging methods associated with bone metabolism in patients with or without renal failure under the age of 45 years with elevated parathyroid hormone levels

Abstract

Objectives: Although bone biopsy is considered the gold standard for the definitive diagnosis of renalosteodystrophy; it is not suitable for routine clinical practice due to its invasive nature. The present study wasaimed to evaluate and compare the bone mineral status using dual energy X-ray absorptiometry of patientswith or without chronic kidney disease in young population with elevated parathyroid hormone levels.Methods: This was a single center, cross-sectional, retrospective study conducted in patients younger than 45years of age. The study was performed in the outpatient clinic of a university hospital. Patients with elevatedparathyroid hormone levels were included.Results: Among them, 29 had renal insufficiency, 158 had normal renal function. Measured bone mineraldensity with dual energy X-ray absorptiometry and laboratory values were collected from patient files. Theprimary end point was to assess the efficiacy of dual energy X-ray absorptiometry in patients with or withoutrenal failure. Except Z score at Ward’s triangle, all of the T and Z scores at lomber, femur neck, trochanteric,and intertrochanteric areas were found significantly lower in patients with chronic kidney disease compared tothose without (p < 0.001).Conclusion: Dual energy X-ray absorptiometry seemed to be a reliable method for detection of osteoporosisin premenopausal female and male patients younger than 45 years of age with or without renal failure withelevated parathyroid hormone levels.