Comparison of Dose-Related Isotretinoin Effects on SD-OCT Parameters in Patients with Acne Vulgaris

Abstract

Purpose: To compare the effects of high- (Group 1) and low-dose (Group 2) systemic isotretinoin effects on spectral domain optic coherence tomography parameters in patients with acne vulgaris. Material and methods: Thirty patients receiving high-dose (>0.5 mg/kg per day) systemic isotretinoin treatment and 32 patients treated with low-dose systemic isotretinoin (0.05). But, at the fourth month visit, temporal and inferior quadrants of pRNFL in patients received high dose isotretinoinwere significantly lower than patients received low dose (p=0.037 and p=0.041, respectively). At the one month after the cessation of treatment, o nly temporal quadrant of pRNFL in Group 1 was signi ficantly lower than Group 2 (p=0.033). No statistically signi ficant difference was observed in other quadrants of pRNFL and mean pRNFL between two groups during the study. Conclusion: Low dose isotretinoin seems to have safety pro file for SFCT, mGCC and pRNFL. However, according to our results, high dose isotretinoin caused pRNFL thinning while caused no SFCT and mGCC thinning. High dose therapy may have a toxic effect on pRNFL, especially temporal and inferior quadrant. Therefore, it may be useful to monitor patients receiving high doses in clinical pra ctice with the SD-OCT.