Two New Seco-abietanoids with Xanthine Oxidase Inhibitory Activity from Cryptomeria japonica D. Don

Abstract

Two new seco-abietanoids, 12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7-oic acid (1) and 7-hydroxy- 7,8-secoabieta-8,12-diene-6,11,14-trione (3), together with one known seco-abietanoid, 12-hydroxy-6-nor-5-oxo-5,6- secoabieta-8,11,13-trien-7-al (2), were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated by mean of spectroscopic analysis, as well as on comparison of NMR data with those of known analogues. At a concentration of 50 μM, compounds 1–3 showed inhibitory activity toward xanthine oxidase by 38.2%, 55.9%, and 23.0%, respectively.