Dergiler / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 2

Three Isoflavonoid Glycosides from the Rhizomes of Achyranthes bidentata and their Protective Effects on H2O2 Induced H9c2 Cardiomyocytes Injury

Three Isoflavonoid Glycosides from the Rhizomes of Achyranthes bidentata and their Protective Effects on H2O2 Induced H9c2 Cardiomyocytes Injury

Yue Lİ, Jun CHİ, Ping WANG, Lingxia ZHANG, Qingxia Lİ, Qingmei FENG, Liping DAİ, Zhimin WANG

Sayfa
110–117
DOI
—

Abstract

A new isoflavonoid glycoside, achyranthoside C (1), along with two known compounds (2 and 3) were isolated from the rhizomes of Achyranthes bidentata. Compounds 1-2 were two rare natural isoflavonoid glycosides with C8 hydroxymethylene derivatization. Their structures were elucidated through comprehensive 1D and 2D NMR, UV, IR, and HRMS analyses. Bioassay results showed all the three compounds had obviously cell-protective effects against H2O2-induced H9c2 cardiomyocytes injury in a concentration -dependent manner.