Dergiler / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 5

Cytotoxic Drimane-type Sesquiterpenoids from the Fungus Aspergillus flavipes 297

Cytotoxic Drimane-type Sesquiterpenoids from the Fungus Aspergillus flavipes 297

Liancheng XU, Guodong LIU, Yu CHEN, Shan LIU, Weihuan LUO, Pengfei HU, Changming HUANG, Xiang JI, Shiping WANG, Guanyi CAO

Sayfa
488–492
DOI
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Abstract

Abstract: Chemical investigation of the marine-derived fungus Aspergillus flavipes 297 led to the isolation and identification of three drimane-type sesquiterpenoids, asperflavinoid A (1) and (6-strobilactone-B) esters of (E,E)-6,7-dihydroxy-2,4-octadienoic acids (2 and 3). Asperflavinoid A (1) was characterized as unseparated diastereomers and its chemical structure was determined by spectroscopic analysis of NMR and MS data. In the cytotoxic assay, compound 1 showed promising inhibitory effects on HepG2 and MKN-45 cell lines.