Dergiler / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 5

A New Iridoid Glucoside from the Stems of Myoporum bontioides (Sieb.et Zucc.) A. Gray

A New Iridoid Glucoside from the Stems of Myoporum bontioides (Sieb.et Zucc.) A. Gray

Vu Dinh HOANG, Tran Thi MINH, Nguyen Thi Viet THANH

Sayfa
426–432
DOI
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Abstract

A phytochemical investigation of the stems of Myoporum bontioides (Sieb. et Zucc.) A. Gray, a semimangrove plant distributed along coastlines of north-eastern Vietnam and some Asian countries led to the isolation of a new iridoid glucoside (1), named myobontioside E, together with fourteen known compounds (2- 15). Their structures were elucidated by means of HR ESI-MS, 1D and 2D NMR spectroscopy as well as comparison with the data reported in the literature. The cytotoxic effects on 8505C, MKN7, HT29, and T24 cell lines were assessed using SRB assay. Only iridoid 2 exhibited weak cytotoxicity against all tested cell lines with IC50 values ranging from 60.19 to 69.14 μM.