İleri maternal yaşın gebelik komplikasyonları ve advers neonatal sonuçlar üzerindeki etkileri

The implications for advanced maternal age on pregnancy complications and adverse neonatal outcomes

Özet

Amaç: Çal›flmam›zda, ileri maternal yafl›n (AMA) 30–34 yafl aras›n- daki hastalara k›yasla ≥35 yafl›ndaki gebelerde maternal ve neonatal sonuçlar üzerindeki etkisini belirlemeyi amaçlad›k. Ayr›ca, kar›flt›r›c› de¤iflkenlerin advers gebelik sonuçlar›n›n geliflimine katk›da bulu- nup bulunmad›¤›n› tespit etmek amac›yla potansiyel kar›flt›r›c›lar›n risk tahminlerini analiz etmeyi amaçlad›k. Yöntem: Bu retrospektif kohort çal›flmas›, do¤um zaman›nda ≥35 yafl›nda olan ve 1 Ocak 2016 ile 31 Aral›k 2020 tarihleri aras›nda üçüncü basamak bir referans hastanesinde do¤um yapan 2284 ge- beyi içermektedir. Bu gebeleri iki alt gruba ayr›ld›: 35–39 yafl ara- s›nda olanlar için erken AMA (EAMA) ve ≥40 yafl›nda olanlar için geç AMA (VAMA). Gebelik komplikasyonlar› ve advers neonatal sonuçlar kaydedildi. Bulgular: Daha genç kad›nlara k›yasla AMA gebelerde; gestasyonel diabetes mellitus (GDM, p

Abstract

Objective: This study aimed to determine the effect of advanced maternal age (AMA) on maternal and neonatal outcomes in preg- nant women aged ≥35 years compared with patients aged 30–34 years. Also, we aimed to analyze the risk estimates of potential con- founders to identify whether these variables contributed to the development of adverse pregnancy outcomes or not. Methods: This retrospective cohort study included 2284 pregnant women aged ≥35 years at the time of delivery who was delivered in a tertiary referral hospital from January 1, 2016, to December 31, 2020. We further classified these women into two subgroups: 35–39 years as early AMA (EAMA), and ≥40 years as very AMA (VAMA). Pregnancy complications and adverse neonatal outcomes were recorded. Results: Compared to younger women, pregnant AMA women had significantly higher risks of complicated pregnancies, including a higher risk of gestational diabetes mellitus (GDM, p