İzole Kroner Arter Ektazili Hastalarda Aterojenik Dislipideminin Araştırılması

Investigation of Atherogenic Dyslipidemia in Patients with İsolated Coronary Artery Ectasia

Özet

ÖZGİRİŞ ve AMAÇ: Koroner arter ektazisinin (KAE) patofizyolojisi açıkça tanımlanamamıştır. Dislipidemi, kardiyovasküler hastalık (KVH) için bağımsız bir risk faktörü olarak kabul edilir. Her ne kadar aterojenik dislipidemi ile KVH arasındaki ilişki iyi bilinse de, izole KAE ile aterojenik dislipidemi hakkında bilgi yoktur. Bu çalışmanın amacı, izole KAE'li hastalarda aterojenik dislipidemiyi değerlendirmektir.YÖNTEM ve GEREÇLER: Hasta grubunda izole KAE olan 91 hasta vardı ve kontrol grubu normal koroner anjiyogramları olan 90 ardışık kişiden oluşuyordu. Serum total kolesterol (TK), trigliserit (TG), düşük yoğunluklu lipoprotein kolesterol (LDL-K), yüksek yoğunluklu lipoprotein kolesterol (HDL-K) ve aterojenik endeksler (aterojenik dislipidemi indeksi, HDL-K olmayan, aterojenik katsayısı, kardiyak risk oranları 1 ve 2) analiz edildi.BULGULAR: Aterojenik dislipidemi indeksi, HDL-K olmayan, aterojenik katsayısı ve kardiyak risk oranları 1 ve 2 izole KAE hastalarında kontrollerden anlamlı olarak daha yüksekti (p

Abstract

ABSTRACTINTRODUCTION: The pathophysiology of coronary artery ectasia (CAE) has not been clearly identified. Dyslipidemia is considered an independent risk factor for cardiovascular disease (CVD). Although the relationship between atherogenicdyslipidemia and CVD is well known, there is no information about atherogenic dyslipidemia with isolated CAE. The aim of the present study was to evaluate the atherogenic dyslipidemia in patients with isolated CAE.METHODS: The patient group included 91 patients with isolated CAE and the control group consisted of 90 consecutive subjects who proved to have normal coronary angiograms. Serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), andatherogenic indices (atherogenic dyslipidemia index, non HDL-C, atherogenic coefficient, cardiac risk ratios 1 and 2) were analyzed.RESULTS: The atherogenic dyslipidemia index, non HDL-C, atherogenic coefficient, and cardiac risk ratios 1 and 2 were significantly greater in the isolated CAE patients than in the controls (p < 0.001; p = 0.001; p = 0.001; p = 0.001; p < 0.001, respectively). The multivariate logistic regression models revealed that atherogenic dyslipidemia index was found to be independent factor predicting isolated CAE (p < 0.001, Odds ratio (OR) = 1.329, 95% Confidence interval (C.I.) = 1.110–1.591).DISCUSSION and CONCLUSION: This is the first study that evaluates the relationship between the atherogenic dyslipidemia and isolated CAE. Our findings suggest that increased atherogenic indices (atherogenic dyslipidemia index, non HDL-C, atherogenic coefficient, cardiac risk ratios 1 and 2) may be involved in the early pathogenesis of the isolated CAE.