Dergiler / Journal of Ankara Medical School / 1997 / Cilt: 19 - Sayı: 3

COPD , platelet functions and N-acetyl cysteine

COPD , platelet functions and N-acetyl cysteine

Sema YAVUZER, Banu OCAKÇIOĞLU, Gülseren KAYABIYIKLIOĞLU, Öznur AKKOCA

Sayfa
121–125
DOI
—

Abstract

In our department previously it has been determined that in COPD (chronic obstructive pulmonary disease) pa¬tients-there is oxidant stress, tendency for hypercoagulability and increase in platelet functions. In the presented study, it was aimed to determine the effect of antioxidant defense supportive treatment on pla¬telet functions. 15 COPD patients were treated by 600 mg/day (3x200 mg) N-Acetyl Cysteine, "ASIST" (Bilim ilaç San. ve Tic. A.Ş) for 3 months and platelet aggregation responses in whole blood to ADP and collagen were exami¬ned before and after treatment. In our study it was observed that N-Acetyl Cysteine treatment decreased the platelet aggregation response in¬duced by collagen significantly (p