The result of gastrocystoplasty in rat model

Abstract

In the presented study, gastrocystoplasty in rats and related biochemical, physiological and histopathological results are discussed. 30 rats were grouped as follows: Control and Sham (Group A), animals with gastrocystoplasty (Group B). Urine pH, blood pH and bicarbonate levels, bladder capacity and end filling pressures were evaluated in all groups. After the gastrocystoplasty, group B showed a statistically significant increase in bladder capacity. Acidu-ria developed in 34 percent of rats in group B. In group A aciduria wasn't noted. No statistically significant differen¬ce was observed in blood pH and bicarbonate levels and end-filling pressure measurements in each group of rats. Significant histopathologic changes of the bladder occurred in the gastrocystoplasty group. In the 15 bladders exa¬mined histologically in group B, 2 had a papilloma on the mucosal surface of the transplanted gastric patch. The bladder mucosa adjacent to the transplanted gastric patch had pronounced hyperplastic and squamous metaplastic changes. Possible etiologies and differences of gastrocystoplasty related pathologic changes between two groups are discussed.